Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00860
Abstract: Multiplexed quantitative analyses of complex proteomes enable deep biological insight. While a multitude of workflows have been developed for multiplexed analyses, the most quantitatively accurate method (SPS-MS3) suffers from long acquisition duty cycles. We built… read more here.
Keywords: sps ms3; real time; platform; database ... See more keywords
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1721899115
Abstract: Significance Next-generation sequencing (NGS) has allowed the comprehensive study of the genome and transcriptome. However, a similarly broad, highly multiplexed, and inexpensive method for proteomics using NGS remains elusive. Here, we describe a phage display-based… read more here.
Keywords: using genetically; surface; highly multiplexed; cell surface ... See more keywords
A highly multiplexed quantitative phosphosite assay for biology and preclinical studies
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Systems Biology"
DOI: 10.15252/msb.202010156
Abstract: Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a… read more here.
Keywords: phosphosite assay; quantitative phosphosite; sigpath; biology ... See more keywords