Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes.
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DOI: 10.1016/j.ymben.2017.01.004
Abstract: Actinomycetes produce a large variety of pharmaceutically active compounds, yet production titers often require to be improved for discovery, development and large-scale manufacturing. Here, we describe a new technique, multiplexed site-specific genome engineering (MSGE) via… read more here.
Keywords: multiplexed site; engineering; specific genome; site specific ... See more keywords