Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65950-2
Abstract: Understanding kinase action requires precise quantitative measurements of their activity in vivo. In addition, the ability to capture spatial information of kinase activity is crucial to deconvolute complex signaling networks, interrogate multifaceted kinase actions, and… read more here.
Keywords: multiplexed spatial; kinase action; prokas; kinase signaling ... See more keywords
Statistical analysis of multiple regions-of-interest in multiplexed spatial proteomics data
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbae522
Abstract: Abstract Multiplexed spatial proteomics reveals the spatial organization of cells in tumors, which is associated with important clinical outcomes such as survival and treatment response. This spatial organization is often summarized using spatial summary statistics,… read more here.
Keywords: spatial proteomics; usepackage; multiplexed spatial; statistical analysis ... See more keywords