Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork
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DOI: 10.1038/s41598-018-21098-2
Abstract: To expand multi-potent progenitors from human trabecular meshwork (TM), we have created a new optimized method on two-dimensional (2D) followed by three–dimensional (3D) Matrigel in modified embryonic stem cell medium supplemented with 5% fetal bovine… read more here.
Keywords: trabecular meshwork; multipotent progenitors; human trabecular; progenitors human ... See more keywords
Eltrombopag preferentially expands haematopoietic multipotent progenitors in human aplastic anaemia
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DOI: 10.1111/bjh.17140
Abstract: Eltrombopag has been added to first‐line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag… read more here.
Keywords: multipotent progenitors; preferentially expands; aplastic anaemia; eltrombopag preferentially ... See more keywords
Ascorbate deficiency increases quiescence and self-renewal in hematopoietic stem cells and multipotent progenitors
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DOI: 10.1182/blood.2024024769
Abstract: Key Points • Deletion of the ascorbate transporter, Slc23a2, increases quiescence and self-renewal potential in HSCs and multipotent progenitors.• Ascorbate deficiency is sufficient to confer long-term self-renewal potential on MPPs. read more here.
Keywords: ascorbate deficiency; self renewal; self; increases quiescence ... See more keywords