Polycystins as components of large multiprotein complexes of polycystin interactors.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109640
Abstract: Naturally occurring mutations in two separate genes, PKD1 and PKD2, are responsible for the vast majority of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases affecting 1… read more here.
Keywords: polycystins components; components large; multiprotein; multiprotein complexes ... See more keywords
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity.
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DOI: 10.1126/science.adv0657
Abstract: Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such complexes and threaten their essential functions remains unexplored. To investigate… read more here.
Keywords: hoap; multiprotein complex; multiprotein; compensatory evolution ... See more keywords