pK50—A Rigorous Indicator of Individual Functional Group Acidity/Basicity in Multiprotic Compounds
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DOI: 10.1021/acs.jcim.3c00187
Abstract: In this work, we show that the apparent pKa measured by standard titration experiments is an insufficient measure of acidity or basicity of organic functional groups in multiprotic compounds—a frequent aspect of lead optimization in… read more here.
Keywords: multiprotic compounds; acidity; functional group; acidity basicity ... See more keywords