Kinetics of diffusion-influenced multisite phosphorylation with enzyme reactivation.
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23533
Abstract: The simplest way to account for the influence of diffusion on the kinetics of multisite phosphorylation is to modify the rate constants in the conventional rate equations of chemical kinetics. We have previously shown that… read more here.
Keywords: multisite phosphorylation; diffusion; rate; enzyme reactivation ... See more keywords
Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2019.12.052
Abstract: Multisite protein phosphorylation plays a critical role in cell regulation [1-3]. It is widely appreciated that the functional capabilities of multisite phosphorylation depend on the order and kinetics of phosphorylation steps, but kinetic aspects of… read more here.
Keywords: pathogenic mutations; multisite phosphorylation; inference multisite; phosphorylation rate ... See more keywords
Structural Basis for Graded Inhibition of CREB:DNA Interactions by Multisite Phosphorylation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01092
Abstract: Phosphorylation of the kinase inducible domain (KID) of the cyclic AMP response element binding transcription factor (CREB) regulates its function through several mechanisms. Transcriptional activation occurs following phosphorylation at serine 133, but multisite phosphorylation in… read more here.
Keywords: creb dna; dna; multisite phosphorylation; creb ... See more keywords
Combined Enrichment/Enzymatic Approach To Study Tightly Clustered Multisite Phosphorylation on Ser-Rich Domains.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00205
Abstract: The regulation of protein function through phosphorylation is often dominated by allosteric interactions and conformational changes. However, alternative mechanisms involving electrostatic interactions also regulate protein function. In particular, phosphorylation of clusters of Ser/Thr residues can… read more here.
Keywords: ser rich; multisite phosphorylation; phosphorylation ser; approach ... See more keywords
Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-04-0118
Abstract: The term M-phase supershift denotes the phosphorylation-dependent substantial increase in the apparent molecular weight of numerous proteins of varied biological functions during M-phase induction. Although the M-phase supershift of multiple key mitotic regulators has been… read more here.
Keywords: multisite phosphorylation; phase supershift; key mitotic; mitotic regulators ... See more keywords
Exploring the intrinsic behaviour of multisite phosphorylation systems as part of signalling pathways
Sign Up to like & getrecommendations! Published in 2018 at "Journal of The Royal Society Interface"
DOI: 10.1098/rsif.2018.0109
Abstract: Multisite phosphorylation is a basic way of chemically encoding substrate function and a recurring feature of cell signalling pathways. A number of studies have explored information processing characteristics of multisite phosphorylation, through studies of the… read more here.
Keywords: multisite phosphorylation; signalling pathways; biology; multisite modification ... See more keywords
The Effect of Multisite Phosphorylation on the Conformational Properties of Intrinsically Disordered Proteins
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222011058
Abstract: Intrinsically disordered proteins are involved in many biological processes such as signaling, regulation, and recognition. A common strategy to regulate their function is through phosphorylation, as it can induce changes in conformation, dynamics, and interactions… read more here.
Keywords: effect multisite; multisite phosphorylation; phosphorylation; disordered proteins ... See more keywords