Toward Drug-Like Multispecific Antibodies by Design
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207496
Abstract: The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions.… read more here.
Keywords: like multispecific; multispecific antibodies; drug like; toward drug ... See more keywords
When three is not a crowd: trispecific antibodies for enhanced cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.81494
Abstract: Despite the clinical success of the first bispecific antibody approved by the FDA against B cell malignancies (blinatumomab), many obstacles remain such as dosing, treatment resistance, and modest efficacy in solid tumors. To overcome these… read more here.
Keywords: multispecific antibodies; three crowd; crowd trispecific; trispecific antibodies ... See more keywords