Novel Purine‐Based Natural Products as Inhibitors of Cholinesterases and Monoamine Oxidases Presenting Potential Multitarget Therapeutics Tackling Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70035
Abstract: Alzheimer's disease (AD) is a complex neurological disorder that arises from multiple factors. The innovative multitarget‐directed ligand (MTDL) approach, which incorporates multiple pharmacophores into one molecule, enhances the development of effective therapeutics for AD. Eighteen… read more here.
Keywords: alzheimer disease; disease; multitarget; purine based ... See more keywords
Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200238
Abstract: Schizophrenia is a complex disease which is best treated with multitarget drugs, such as atypical antipsychotics. Previously, using structure‐based virtual screening, we found a virtual hit, D2AAK1, with nanomolar affinity for dopamine and serotonin receptors… read more here.
Keywords: multitarget; antipsychotics effect; derivatives d2aak1; d2aak1 potential ... See more keywords
Design of Improved Antidiabetic Drugs: A Journey from Single to Multitarget Agents
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200320
Abstract: Multifactorial diseases exhibit a complex pathophysiology with several factors contributing to their pathogenesis and development. Examples of such disorders are neurodegenerative (e. g. Alzheimer's, Parkinson's) and cardiovascular diseases (e. g. atherosclerosis, metabolic syndrome, diabetes II). Traditional therapeutic… read more here.
Keywords: multitarget agents; improved antidiabetic; multitarget; antidiabetic drugs ... See more keywords
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Research Reviews"
DOI: 10.1002/med.22045
Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major health threat globally. Its prevalence is forecasted to exponentially increase during the next 30 years due to the global aging population. Currently,… read more here.
Keywords: alzheimer disease; disease; multitarget; innovative pathological ... See more keywords
Indazolylketones as new multitarget cannabinoid drugs.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.030
Abstract: Multitarget cannabinoids could be a promising therapeutic strategic to fight against Alzheimer's disease. In this sense, our group has developed a new family of indazolylketones with multitarget profile including cannabinoids, cholinesterase and BACE-1 activity. A… read more here.
Keywords: new multitarget; multitarget; chemistry; indazolylketones new ... See more keywords
Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112743
Abstract: Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease (AD). In our present research, a number of xanthone derivatives were first designed… read more here.
Keywords: alzheimer disease; multitarget; design new; inhibitory activity ... See more keywords
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.09.086
Abstract: Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for… read more here.
Keywords: ischemia reperfusion; reperfusion injury; cardioprotection; multitarget ... See more keywords
Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01255
Abstract: Hybrid compounds containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids were designed with the aid of docking and molecular mechanics studies. Following the synthesis of the… read more here.
Keywords: fasudil; hybrid fasudil; multitarget; multitarget hybrid ... See more keywords
Design, Synthesis, and Bioevaluation of Indole Core Containing 2-Arylidine Derivatives of Thiazolopyrimidine as Multitarget Inhibitors of Cholinesterases and Monoamine Oxidase A/B for the Treatment of Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06344
Abstract: In continuation of our previous study to identify multitarget inhibitors of cholinesterases (ChEs) and monoamine oxidase (MAOs) isoforms, we synthesized and evaluated 2-arylidine derivatives of thiazolopyrimidine for the treatment of Alzheimer disease. Three series of… read more here.
Keywords: multitarget inhibitors; multitarget; monoamine oxidase; arylidine derivatives ... See more keywords
An exclusive computational insight toward molecular mechanism of MMV007571, a multitarget inhibitor of Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1700165
Abstract: Abstract Recently, two Malaria Box molecules namely MMV007571 and MMV020439 well known inhibitors of New Permeability Pathway (NPP) function also showed a secondary phenotype of inhibition of enzyme Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) and cytochrome… read more here.
Keywords: inhibitor; multitarget; plasmodium falciparum; plasmodium ... See more keywords
A Dynamic Multitarget Obstacle Tracking and Monitoring Method for Vehicle Routing Based on Multiple Constraint Composite Perception Association Filtering
Sign Up to like & getrecommendations! Published in 2024 at "IEEE Access"
DOI: 10.1109/access.2024.3444054
Abstract: Multitarget tracking technology is the core topic in the field of intelligent driving. Multi-target complex manoeuvring, measurement outliers and unknown environmental prior parameters strongly affect the tracking accuracy of the target state. To address the… read more here.
Keywords: multitarget; algorithm; target; association ... See more keywords