7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
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DOI: 10.1002/cmdc.202000454
Abstract: This study explores the potential of 7‐amidocoumarins as multitarget agents against Parkinson's and Alzheimer's diseases, by modulating the substitution patterns within the scaffold. Sixteen compounds were synthesized via 7‐amino‐4‐methylcoumarin acylation, and in vitro evaluation of the… read more here.
Keywords: substitution pattern; amidocoumarins multitarget; multitarget agents; substitution ... See more keywords
Design of Improved Antidiabetic Drugs: A Journey from Single to Multitarget Agents
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DOI: 10.1002/cmdc.202200320
Abstract: Multifactorial diseases exhibit a complex pathophysiology with several factors contributing to their pathogenesis and development. Examples of such disorders are neurodegenerative (e. g. Alzheimer's, Parkinson's) and cardiovascular diseases (e. g. atherosclerosis, metabolic syndrome, diabetes II). Traditional therapeutic… read more here.
Keywords: multitarget agents; improved antidiabetic; multitarget; antidiabetic drugs ... See more keywords
Bis-γ-carbolines as new potential multitarget agents for Alzheimer’s disease
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DOI: 10.1515/pac-2019-1206
Abstract: Abstract A new series of homobivalent Dimebon analogs, bis-γ-carbolines with alkylene, phenylenedialkylene, and triazole-containing spacers, was synthesized. Doubling the γ-carboline pharmacophore increased inhibitory potency against acetylcholinesterase (AChE) compared with Dimebon, while keeping Dimebon’s anti-butyrylcholinesterase activity;… read more here.
Keywords: agents alzheimer; alzheimer disease; multitarget agents; bis carbolines ... See more keywords