Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies
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DOI: 10.1021/acs.jmedchem.0c01376
Abstract: Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-d-Arg-Aba-β-Ala-NH2 (KGOP01) was fused to NT(8-13) analogues. Since the NTS1 receptor has been… read more here.
Keywords: multitarget peptides; affinity; optimized opioid; peptides design ... See more keywords
The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01456
Abstract: Compared with single-target drugs, multitarget drugs may improve the safety and efficacy of the treatment of multifactorial diseases. However, few multitarget drugs are on the market or in clinical trials currently, and multitarget small molecules… read more here.
Keywords: multifactorial diseases; treatment multifactorial; design; multitarget peptides ... See more keywords