Investigational multitargeted kinase inhibitors in development for head and neck neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1581172
Abstract: ABSTRACT Introduction: Despite advances in treatment, head and neck squamous cell carcinoma (HNSCC) survival rates remain stagnant. Current treatment is associated with significant toxicities and includes chemotherapy, radiation, surgery, and few targeted treatments. Targeted treatments,… read more here.
Keywords: kinase inhibitors; targeted treatments; multitargeted kinase; head neck ... See more keywords
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13773
Abstract: Gastrointestinal stromal tumor (GIST) is a type of KIT‐driven cancer. KIT gene mutations are found in approximately 80% of GISTs, and most of these mutations occur in exon 9 and exon 11. Imatinib has been… read more here.
Keywords: multitargeted kinase; gastrointestinal stromal; kit; stromal tumor ... See more keywords