Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200364
Abstract: There is an emerging interest in utilizing synthetic multivalent inhibitors that comprise of multiple inhibitor moieties linked on a common scaffold to achieve strong and selective enzyme inhibition. As multivalent inhibition is impacted by valency… read more here.
Keywords: inhibition; valency linker; linker; linker length ... See more keywords
Multivalent Angiomotin‐like 1 and Yes‐associated protein form a dynamic complex
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4295
Abstract: Multivalent complexes formed between the cancer‐promoting transcriptional co‐activator, Yes‐associated protein (YAP), and proteins containing short linear motifs of type PPxY modulate cell proliferation and are attractive therapeutic targets. However, challenges producing PPxY polypeptides containing the… read more here.
Keywords: amotl1; yes associated; ppxy; angiomotin like ... See more keywords
Unique therapeutic properties and preparation methodology of multivalent rituximab‐lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.04.024
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Therapeutic monoclonal antibodies hold great promise in the treatment of cancer and other diseases, but their unclear mechanism of action makes it difficult to identify features that will… read more here.
Keywords: methodology; preparation methodology; rtx; lipid nanoparticles ... See more keywords
Electrochemical characterization of nanocrystalline RuO 2 with aqueous multivalent (Be 2+ and Al 3+ ) sulfate electrolytes for asymmetric supercapacitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alloys and Compounds"
DOI: 10.1016/j.jallcom.2017.11.184
Abstract: Abstract Ruthenium oxide (RuO2) is one of the most investigated electrode materials due to its unique characteristics, such as high reversibility and high capacitance, etc. However, it has always been tested with univalent electrolyte systems… read more here.
Keywords: characterization nanocrystalline; sulfate; sulfate electrolytes; charge storage ... See more keywords
A comparison of multivalent and bivalent vaccination strategies for the control of virulent ovine footrot.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.02.011
Abstract: Virulent footrot is a significant economic and animal welfare concern. The disease can be treated, controlled, and eliminated with vaccine, but selecting the appropriate vaccination strategy can be challenging. There are two main strategies: outbreak… read more here.
Keywords: vaccine; bivalent vaccination; bivalent vaccines; multivalent ... See more keywords
Determinants of Superselectivity—Practical Concepts for Application in Biology and Medicine
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.2c00672
Abstract: Conspectus Multivalent interactions are common in biological systems and are also widely deployed for targeting applications in biomedicine. A unique feature of multivalent binding is “superselectivity”. Superselectivity refers to the sharp discrimination of surfaces (e.g.,… read more here.
Keywords: recognition; application; medicine; multivalent ... See more keywords
“Clickable” Polymer Brush Interfaces: Tailoring Monovalent to Multivalent Ligand Display for Protein Immobilization and Sensing
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00298
Abstract: Facile and effective functionalization of the interface of polymer-coated surfaces allows one to dictate the interaction of the underlying material with the chemical and biological analytes in its environment. Herein, we outline a modular approach… read more here.
Keywords: thiol; polymer; clickable polymer; containing molecules ... See more keywords
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00560
Abstract: Multivalent interactions are a key characteristic of protein-carbohydrate recognition. Phospholipid-based liposomes have been explored as a popular platform for multivalent presentation of glycans, but this platform has been plagued by the instability of typical liposomal… read more here.
Keywords: glycan ligands; density; catanionic vesicles; carbohydrate ... See more keywords
Thiodigalactoside–Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.8b00047
Abstract: Galectin inhibitors are urgently needed to understand the mode of action and druggability of different galectins, but potent and selective agents still evade researchers. Small-sized inhibitors based on thiodigalactoside (TDG) have shown their potential while… read more here.
Keywords: multivalent; serum albumin; bovine serum; potency ... See more keywords
NASICON Na3V2(PO4)3 Enables Quasi-Two-Stage Na+ and Zn2+ Intercalation for Multivalent Zinc Batteries
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.0c00004
Abstract: Identifying positive electrode materials capable of reversible multivalent electrochemistry in electrolytes containing divalent ions such as Mg2+, Ca2+, and Zn2+ at high operating potentials remain... read more here.
Keywords: nasicon na3v2; quasi two; po4 enables; na3v2 po4 ... See more keywords
Electrostatic Correlation Induced Ion Condensation and Charge Inversion in Multivalent Electrolytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00607
Abstract: The study of the electrical double layer lies at the heart of colloidal and interfacial science. The standard mean-field Poisson-Boltzmann (PB) theory is incapable of modeling many phenomena originating from ion correlation. An important example… read more here.
Keywords: charge inversion; ion condensation; multivalent; charge ... See more keywords