Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis.
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DOI: 10.1039/d1nr08090c
Abstract: The misfolding and aggregation of human islet amyloid polypeptide (IAPP) into β-sheet-enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP amyloidogenesis, but their preparation is usually complicated and expensive.… read more here.
Keywords: multivalent antibody; amyloidogenesis; conformation; human islet ... See more keywords