DNA frameworks equipped with high-affinity multivalent aptamers for the reliable and amplified detection of a specific membrane protein.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc04334d
Abstract: A tetrahedral DNA framework-based fluorescent probe is programmed with multivalent aptamers for the precise targeting of membrane nucleolin and an initiator strand to trigger a hybridization chain reaction. Benefiting from multivalent aptamer targeting and HCR… read more here.
Keywords: amplified detection; multivalent aptamers; reliable amplified; membrane ... See more keywords
Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.807498
Abstract: Chemotherapy, as one of the principal modalities for cancer therapy, is limited by its non-specific and inefficient delivery to tumors. To overcome these limitations, we report herein a dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) to… read more here.
Keywords: dna hydrogel; delivery; therapy; dual targeted ... See more keywords