Modulating binding affinity, specificity and configurations by multivalent interactions.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.04.017
Abstract: Biological functions of proteins rely on their specific interactions with binding partners. Many proteins contain multiple domains, which can bind to their targets that often have more than one binding site, resulting in multivalent interactions.… read more here.
Keywords: domain; binding affinity; multivalent interactions; affinity specificity ... See more keywords
Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase.
Sign Up to like & getrecommendations! Published in 2018 at "Structure"
DOI: 10.1016/j.str.2017.11.003
Abstract: Many regulatory proteins, including the transcription factor c-Jun, are highly enriched in disordered protein regions that govern growth, division, survival, differentiation, and response to signals. The stability of c-Jun is controlled by poorly understood regulatory… read more here.
Keywords: jun; ubiquitin ligase; interactions fbw7; multivalent interactions ... See more keywords
Biological recognition at interfaces involving dendritic molecules
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Journal"
DOI: 10.1038/s41428-018-0168-x
Abstract: Dendrimers, a type of dendritic molecule, have a well-defined structure with a homogeneous molecular weight and precise multiple terminal groups. These characteristics are favorable for both research and development, which require accuracy and multivalency. This… read more here.
Keywords: biological functionality; biological recognition; loosely packed; packed terminals ... See more keywords
In situ enzymatic control of colloidal phoresis and catalysis through hydrolysis of ATP
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47912-2
Abstract: The ability to sense chemical gradients and respond with directional motility and chemical activity is a defining feature of complex living systems. There is a strong interest among scientists to design synthetic systems that emulate… read more here.
Keywords: control; hydrolysis atp; multivalent interactions; activity ... See more keywords
NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220056
Abstract: Abstract The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein–protein interactions are relatively static and… read more here.
Keywords: nmr insights; interactions intrinsically; intrinsically disordered; multivalent interactions ... See more keywords
Cep57 regulates human centrosomes through multivalent interactions
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2305260121
Abstract: Significance Cell division is a vital process in development. Errors in cell division can lead to disorders and cancer. At the heart of this process is the centrosome, a membrane-less organelle of hundreds of proteins… read more here.
Keywords: regulates human; human centrosomes; multivalent interactions; cep57 regulates ... See more keywords