Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13018
Abstract: As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin‐1 and SNAP‐25 into a nonfusogenic product that precludes synaptobrevin‐2 entry, raising the question how the assembly of the… read more here.
Keywords: snare; snare complex; syntaxin; munc18 ... See more keywords
Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming
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DOI: 10.1038/ncomms15293
Abstract: The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A domain of Munc13 inhibits the priming function by homodimerization,… read more here.
Keywords: vesicle docking; docking priming; c2a domain; munc13 ... See more keywords
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64164-w
Abstract: Degeneration of neuromuscular synapses is a key pathological feature of spinal muscular atrophy (SMA), yet cellular mechanisms underlying synapse dysfunction remain elusive. Here, we show that pharmacological stimulation with Roscovitine triggers the assembly of Munc13-1… read more here.
Keywords: munc13; spinal muscular; pathology; muscular atrophy ... See more keywords
A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2508915122
Abstract: Significance Munc13-1 is a master regulator of neurotransmitter release, which features a long low-complexity region in its N terminus. Here, we identified a functional motif in this region, termed polyE, which is unique to Munc13-1… read more here.
Keywords: munc13; sequence confers; negatively charged; charged sequence ... See more keywords
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.773209
Abstract: Selective distribution of proteins in presynaptic active zones (AZs) is a prerequisite for generating postsynaptic target cell type-specific differences in presynaptic vesicle release probability (Pv) and short-term plasticity, a characteristic feature of cortical pyramidal cells… read more here.
Keywords: mglur1 expressing; munc13; expressing interneurons; presynaptic active ... See more keywords
Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22567
Abstract: Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how the functions of the multiple domains of Munc13–1 are coordinated. The crystal… read more here.
Keywords: crystal structure; presynaptic plasticity; neurotransmitter release; structure ... See more keywords
Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.79433
Abstract: Munc13 proteins are priming factors for SNARE-dependent exocytosis, which are activated by diacylglycerol (DAG)-binding to their C1-domain. Several Munc13 paralogs exist, but their differential roles are not well understood. We studied the interdependence of phorbolesters… read more here.
Keywords: munc13; munc13 ubmunc13; core vesicle; secretion ... See more keywords