Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13018
Abstract: As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin‐1 and SNAP‐25 into a nonfusogenic product that precludes synaptobrevin‐2 entry, raising the question how the assembly of the… read more here.
Keywords: snare; snare complex; syntaxin; munc18 ... See more keywords
MUNC18–1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-017-0498-5
Abstract: While Munc18–1 interacts with Syntaxin1 and controls the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex to regulate presynaptic vesicle fusion in developed neurons, this molecule is likely to be involved in brain… read more here.
Keywords: vesicle; munc18; gene abnormalities; development ... See more keywords
Reduced Dynamin-I levels in neurons lacking MUNC18-1.
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DOI: 10.1242/jcs.260132
Abstract: MUNC18-1/Syntaxin binding protein-1 (Stxbp1), binds Syntaxin-1. Together, these proteins regulate synaptic vesicle exocytosis and have a separate role in neuronal viability. In MUNC18-1/Stxbp1 null mutant neurons, Syntaxin-1 protein levels are 70% reduced. Here, we show… read more here.
Keywords: null mutant; stxbp1 null; munc18; neurons lacking ... See more keywords
Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1
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DOI: 10.1523/eneuro.0186-22.2022
Abstract: Abstract Absence of presynaptic protein MUNC18-1 (gene: Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immature Stxbp1 knock-out (KO) cells to discover… read more here.
Keywords: depletion; munc18; synaptic developmental; dysregulation synaptic ... See more keywords