Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate: A combined spectroscopic and computational investigation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.12.124
Abstract: Peptidoglycan (PG) is the main constituent of the bacterial cell wall. The enzyme UDP‑N‑acetylglucosamine enolpyruvyl transferase (MurA) catalyzes the transfer of enolpyruvate from phosphoenolpyruvate to uridinediphospho‑N‑acetylglucosamine, which is the first committed step of PG biosynthesis.… read more here.
Keywords: unfolding acinetobacter; baumannii mura; metastable intermediate; mura ... See more keywords
An Efficient Optical Mura Compensation System for Large Liquid-Crystal Display Panels
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3192293
Abstract: Increased mura defect rates as liquid-crystal display (LCD) sizes and resolutions increase have become an issue of the utmost concern for large LCD panel makers. To address this issue, an efficient optical mura compensation (referred… read more here.
Keywords: system; optical mura; crystal display; efficient optical ... See more keywords
Discovery of MurA Inhibitors as Novel Antimicrobials through an Integrated Computational and Experimental Approach
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11040528
Abstract: The bacterial cell wall is essential for protecting bacteria from the surrounding environment and maintaining the integrity of bacteria cells. The MurA enzyme, which is an essential enzyme involved in bacterial cell wall synthesis, could… read more here.
Keywords: mura inhibitors; mic value; growth inhibition; discovery mura ... See more keywords
Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15121484
Abstract: Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyclic covalent fragment… read more here.
Keywords: heterocyclic electrophiles; generation heterocyclic; electrophiles small; covalent ... See more keywords