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   Articles with "mura" as a keyword



Role of UDP‐N‐acetylmuramic acid in the regulation of MurA activity revealed by molecular dynamics simulations

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recommendations! Published in 2024 at "Protein Science"

DOI: 10.1002/pro.4969

Abstract: The peptidoglycan biosynthesis pathway plays a vital role in bacterial cells, and facilitates peptidoglycan layer formation, a fundamental structural component of the bacterial cell wall. The enzymes in this pathway are candidates for antibiotic development,… read more here.

Keywords: role; mura; molecular dynamics; acetylmuramic acid ... See more keywords

Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate: A combined spectroscopic and computational investigation.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.12.124

Abstract: Peptidoglycan (PG) is the main constituent of the bacterial cell wall. The enzyme UDP‑N‑acetylglucosamine enolpyruvyl transferase (MurA) catalyzes the transfer of enolpyruvate from phosphoenolpyruvate to uridinediphospho‑N‑acetylglucosamine, which is the first committed step of PG biosynthesis.… read more here.

Keywords: unfolding acinetobacter; baumannii mura; metastable intermediate; mura ... See more keywords

Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-51150-x

Abstract: The biological aspects of infancy within late Upper Palaeolithic populations and the role of southern refugia at the end of the Last Glacial Maximum are not yet fully understood. This study presents a multidisciplinary, high… read more here.

Keywords: upper palaeolithic; palaeolithic infant; history; infant grotta ... See more keywords

Vertical-Line Mura Defect Detection for TFT-LCDs

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recommendations! Published in 2024 at "IEEE Access"

DOI: 10.1109/access.2024.3486567

Abstract: Mura defects, which manifest as irregularities in brightness and color on display screens, present persistent challenges for Thin Film Transistor Liquid Crystal Display (TFT-LCD) manufacturers. While traditional methods effectively detect significant abnormalities in vertical-line inspections,… read more here.

Keywords: detection; vertical line; mura; tft ... See more keywords

An Efficient Optical Mura Compensation System for Large Liquid-Crystal Display Panels

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recommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"

DOI: 10.1109/tim.2022.3192293

Abstract: Increased mura defect rates as liquid-crystal display (LCD) sizes and resolutions increase have become an issue of the utmost concern for large LCD panel makers. To address this issue, an efficient optical mura compensation (referred… read more here.

Keywords: system; optical mura; crystal display; efficient optical ... See more keywords

Discovery of MurA Inhibitors as Novel Antimicrobials through an Integrated Computational and Experimental Approach

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recommendations! Published in 2022 at "Antibiotics"

DOI: 10.3390/antibiotics11040528

Abstract: The bacterial cell wall is essential for protecting bacteria from the surrounding environment and maintaining the integrity of bacteria cells. The MurA enzyme, which is an essential enzyme involved in bacterial cell wall synthesis, could… read more here.

Keywords: mura inhibitors; mic value; growth inhibition; discovery mura ... See more keywords

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15121484

Abstract: Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyclic covalent fragment… read more here.

Keywords: heterocyclic electrophiles; generation heterocyclic; electrophiles small; covalent ... See more keywords