Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2.
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DOI: 10.1021/acsinfecdis.6b00154
Abstract: Genetic mutations in the innate immune receptor nucleotide-binding oligomerization domain-containing 2 (Nod2) have demonstrated increased susceptibility to Crohn's disease, an inflammatory bowel disease that is hypothesized to be accompanied by changes in the gut microbiota.… read more here.
Keywords: leucine rich; lrr domain; rich repeat; muramyl dipeptide ... See more keywords
Muramyl Dipeptide Induces Reactive Oxygen Species Generation Through the NOD2/COX-2/NOX4 Signaling Pathway in Human Umbilical Vein Endothelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000581
Abstract: Abstract: Vascular endothelium dysfunction caused by oxidative stress accelerates the pathologic process of cardiovascular diseases. NOD2, an essential receptor of innate immune system, has been demonstrated to play a critical role in atherosclerosis. Here, the… read more here.
Keywords: reactive oxygen; mdp; generation; cox nox4 ... See more keywords
Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer’s disease
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DOI: 10.1186/s12974-020-01893-3
Abstract: Background Muramyl dipeptide (MDP) is a component derived from minimal peptidoglycan motif from bacteria, and it is a ligand for the NOD2 receptor. Peripheral administration of MDP converts Ly6C high into Ly6C low monocytes. Previously,… read more here.
Keywords: muramyl dipeptide; monocyte subsets; mouse model; pathology ... See more keywords
Crohn's Disease and Related Inflammatory Diseases: From many Single Hypotheses to one "Superhypothesis"
Sign Up to like & getrecommendations! Published in 2018 at "Veterinarni Medicina"
DOI: 10.17221/7822-vetmed
Abstract: The aetiology of Crohn's disease and paratuberculosis are the subjects of intensive study and also frequently, of dispute. However, a number of other nosological entities have a similar history, namely type 1 dia - betes,… read more here.
Keywords: muramyl dipeptide; inflammatory diseases; disease; crohn disease ... See more keywords
Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin.2020.03.112
Abstract: The relationship between chronic bacterial colonization in the brain and Alzheimer's disease is attracting extensive attention. Recent studies indicated that the components of bacterial biofilm drive the amyloid-β production. Muramyl dipeptide, the minimal bioactive peptidoglycan… read more here.
Keywords: p38 mapk; production; mapk bace1; muramyl dipeptide ... See more keywords