Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.12.002
Abstract: Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model pathogen for investigating C. trachomatis pathogenesis, readily spreads from the mouse genital tract… read more here.
Keywords: gastrointestinal tract; muridarum; tract; tract gastrointestinal ... See more keywords
Induction of protection in mice against a respiratory challenge by a vaccine formulated with exosomes isolated from Chlamydia muridarum infected cells
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-00235-x
Abstract: The goal of this study was to determine if exosomes, isolated from Chlamydia muridarum infected HeLa cells (C. muridarum-exosomes), induce protective immune responses in mice following vaccination using CpG plus Montanide as adjuvants. Exosomes, collected… read more here.
Keywords: isolated chlamydia; muridarum; exosomes isolated; chlamydia muridarum ... See more keywords
GlgA plays an important role in the induction of hydrosalpinx by chlamydia muridarum.
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens and disease"
DOI: 10.1093/femspd/ftaa027
Abstract: While glycogen synthase A deficiency can reduce the growth and proliferation of Chlamydia muridarum, the effect of glycogen synthase A on the pathogenic process of Chlamydia muridarum remains unclear. To characterize the effect of glycogen… read more here.
Keywords: muridarum; glycogen synthase; chlamydia muridarum;
A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains.
Sign Up to like & getrecommendations! Published in 2019 at "Pathogens and disease"
DOI: 10.1093/femspd/ftz017
Abstract: OBJECTIVE This study is to investigate the functions of newly discovered genes in Chlamydia muridarum (C. muridarum) strains with single gene differences. METHODS Using whole genome sequencing and plaque formation assays, C. muridarum parental and… read more here.
Keywords: muridarum strains; muridarum; study; chlamydia muridarum ... See more keywords
A Minimal Replicon Enables Efficacious, Species-Specific Gene Deletion in Chlamydia and Extension of Gene Knockout Studies to the Animal Model of Infection Using Chlamydia muridarum
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00453-22
Abstract: The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various animals, including humans. Although chlamydial species share many aspects of the typical intracellular lifestyle, such as the biphasic developmental cycle and the preference… read more here.
Keywords: infection; chlamydia; muridarum; model ... See more keywords
Role of TRAIL-R in Primary and Secondary Genital and Respiratory Chlamydia muridarum Infections in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01617-22
Abstract: TNF-related apoptosis-inducing ligand receptor (TRAIL-R) is involved in suppressing inflammatory responses. Bacterial pathogens such as Chlamydia spp. elicit inflammatory responses in humans following genital, ocular, and respiratory infections. ABSTRACT The tumor necrosis factor (TNF)-related apoptosis-inducing… read more here.
Keywords: trail; inflammatory responses; primary secondary; muridarum ... See more keywords
Neisseria gonorrhoeae Coinfection during Chlamydia muridarum Genital Latency Does Not Modulate Murine Vaginal Bacterial Shedding
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04500-22
Abstract: Our work builds upon the limited understanding of C. muridarum/N. gonorrhoeae coinfection. Previously, N. gonorrhoeae infection of mice with acute (actively replicating) vaginal C. muridarum infection was shown to increase recovery of viable vaginal N.… read more here.
Keywords: muridarum infection; gonorrhoeae coinfection; gonorrhoeae; muridarum ... See more keywords
The Structural Integrity of Plasmid-Encoded Pgp3 Is Essential for Induction of Hydrosalpinx by Chlamydia muridarum
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00013
Abstract: Pgp3 consists of globular N- and C-terminal domains connected by a triple-helical coiled-coil middle domain. We demonstrated previously that Pgp3 is required for induction of hydrosalpinx by Chlamydia muridarum. We constructed C. muridarum transformants harboring… read more here.
Keywords: muridarum; induction hydrosalpinx; pgp3; hydrosalpinx ... See more keywords