Novel Murine Glioblastoma Models That Reflect the Immunotherapy Resistance Profile of Human Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noad025
Abstract: BACKGROUND The lack of murine glioblastoma models that mimic the immunobiology of human disease has impeded basic and translational immunology research. We therefore developed murine glioblastoma stem cell lines derived from Nestin-CreERT2QkL/L; Trp53L/L; PtenL/L (QPP)… read more here.
Keywords: glioblastoma models; glioblastoma; human disease; brain ... See more keywords
Syngeneic murine glioblastoma models: reactionary immune changes and immunotherapy intervention outcomes.
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgical focus"
DOI: 10.3171/2021.11.focus21556
Abstract: Glioblastoma is the most common primary malignant brain neoplasm with dismal 10-year survival rates of < 1%. Despite promising preliminary results from several novel therapeutic agents, clinical responses have been modest due to several factors,… read more here.
Keywords: glioblastoma models; syngeneic murine; models reactionary; murine glioblastoma ... See more keywords