Developmental cues license megakaryocyte priming in murine hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006861
Abstract: Key Points • The fetal-to-adult transition in HSC states is associated with a global acquisition of megakaryocytic chromatin accessibility signatures.• The developmentally restricted expression of LIN28B suppresses establishment of an Mk-biased HSC pool early in… read more here.
Keywords: megakaryocyte priming; developmental cues; murine hematopoietic; cues license ... See more keywords
Notch‐Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.5966/sctm.2016-0112
Abstract: The hematopoietic syndrome of acute radiation syndrome (h‐ARS) is characterized by severe bone marrow aplasia, resulting in a significant risk for bleeding, infections, and death. To date, clinical management of h‐ARS is limited to supportive… read more here.
Keywords: murine hematopoietic; medicine; hematopoietic stem; stem ... See more keywords