Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
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DOI: 10.3390/ijms24076863
Abstract: 3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic N-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free radicals that initiate the prooxidant processes. In order to clarify… read more here.
Keywords: tpz; tirapazamine; murine hepatoma; expression ... See more keywords