Efficient N-tailing of blunt DNA ends by Moloney murine leukemia virus reverse transcriptase
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41769
Abstract: Moloney murine leukemia virus reverse transcriptase (MMLV-RT) is a widely used enzyme for cDNA synthesis. Here we show that MMLV-RT has a strong template-independent polymerase activity using blunt DNA ends as substrate that generates 3′… read more here.
Keywords: moloney murine; dna; murine leukemia; dna ends ... See more keywords
Moloney Murine Leukemia Virus p12 Is Required for Histone Loading onto Retroviral DNAs
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DOI: 10.1128/jvi.00495-21
Abstract: Incoming retroviral DNAs are rapidly loaded with nucleosomal histones upon entry into the nucleus and before integration into the host genome. The entry of murine leukemia virus DNA into the nucleus occurs only upon dissolution… read more here.
Keywords: leukemia virus; dna; retroviral dnas; p12 ... See more keywords
BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01478-22
Abstract: In this study, we have shown that the in vivo replication of murine leukemia virus happens independently of BET proteins, which are key host determinants involved in retroviral integration site selection. This finding opens a… read more here.
Keywords: integration; leukemia virus; murine leukemia; w390a mlv ... See more keywords