Liraglutide enhances the effect of checkpoint blockade through the inhibition of neutrophil extracellular traps in murine lung and liver cancers.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13499
Abstract: Glucagon-like peptide-1 (GLP-1) regulates glycemic excursions by augmenting insulin production and inhibiting glucagon secretion. Liraglutide, a long-acting GLP-1 analog, can improve glycemic control for treating type 2 diabetes and prevent neutrophil extravasation in inflammation. Here,… read more here.
Keywords: inhibition; lung liver; liver cancers; murine lung ... See more keywords
Knockdown of circRNA Paralemmin 2 Ameliorates Lipopolysaccharide-induced Murine Lung Epithelial Cell Injury by Sponging miR-330-5p to Reduce ROCK2 Expression.
Sign Up to like & getrecommendations! Published in 2022 at "Immunological investigations"
DOI: 10.1080/08820139.2022.2027961
Abstract: Previous data have reported the high expression of circRNA paralemmin 2 (circPALM2) in mice with acute lung injury (ALI). However, the role of circPALM2 in ALI pathogenesis remains unclear. The study aims to reveal the… read more here.
Keywords: murine lung; injury; circpalm2; mir 330 ... See more keywords
IL10 deficiency promotes alveolar enlargement and lymphoid dysmorphogenesis in the aged murine lung
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DOI: 10.1111/acel.13130
Abstract: The connection between aging‐related immune dysfunction and the lung manifestations of aging is poorly understood. A detailed characterization of the aging IL10‐deficient murine lung, a model of accelerated aging and frailty, reconciles features of both… read more here.
Keywords: enlargement; murine lung; il10 deficient; cell ... See more keywords
In Vivo Pharmacokinetic/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model
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DOI: 10.1128/aac.00909-19
Abstract: Levonadifloxacin is a novel benzoquinolizine subclass of fluoroquinolone, active against quinolone-resistant Staphylococcus aureus. A phase 3 trial for levonadifloxacin and its oral prodrug was recently completed. The present study identified area under the concentration-time curve… read more here.
Keywords: neutropenic murine; murine lung; staphylococcus aureus; lung infection ... See more keywords
TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung
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DOI: 10.1186/s12931-019-1264-y
Abstract: BackgroundIn the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell types that support the structure… read more here.
Keywords: tbx2; murine lung; positive cells; tbx2 positive ... See more keywords