Monoallelic IRF5 deficiency in B cells prevents murine lupus
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DOI: 10.1172/jci.insight.141395
Abstract: Gain-of-function polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are associated with an increased risk of developing systemic lupus erythematosus. However, the IRF5-expressing cell type(s) responsible for lupus pathogenesis in vivo is not… read more here.
Keywords: irf5; deficiency cells; monoallelic irf5; murine lupus ... See more keywords
Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
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DOI: 10.1172/jci120859
Abstract: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after infiltrating the kidney. The current paradigm suggests that kidney-infiltrating T… read more here.
Keywords: lupus nephritis; murine lupus; lupus; infiltrating cells ... See more keywords
Potential genetic basis of B cell hyperactivation in murine lupus models
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DOI: 10.1177/09612033211018264
Abstract: Background Lupus B cells not only produce autoantibodies against nuclear antigens but also provide co-stimulation to T cells. However, there is still a lack of comprehensive understanding of the mechanism underlying lupus B cell hyperactivation.… read more here.
Keywords: cell hyperactivation; lupus models; murine lupus; lupus ... See more keywords
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages
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DOI: 10.3389/fimmu.2018.00135
Abstract: The generation of CD138+ phagocytic macrophages with an alternative (M2) phenotype that clear apoptotic cells from tissues is defective in lupus. Liver X receptor-alpha (LXRα) is an oxysterol-regulated transcription factor that promotes reverse cholesterol transport… read more here.
Keywords: lxr; alveolar hemorrhage; liver receptor; diffuse alveolar ... See more keywords