Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease
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DOI: 10.1002/glia.23182
Abstract: The contribution of reactive gliosis to the pathological phenotype of Alzheimer's disease (AD) opened the way for therapeutic strategies targeting glial cells instead of neurons. In such context, connexin hemichannels were proposed recently as potential… read more here.
Keywords: boldine treatment; alzheimer disease; glial hemichannels; neuronal suffering ... See more keywords
Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood–brain barrier disruption in a murine model of osmotic demyelination syndrome
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DOI: 10.1002/glia.23268
Abstract: The osmotic demyelination syndrome (ODS) is a non‐primary inflammatory disorder of the central nervous system myelin that is often associated with a precipitous rise of serum sodium concentration. To investigate the physiopathology of ODS in… read more here.
Keywords: murine model; demyelination; brain; osmotic demyelination ... See more keywords
DWI and IVIM Imaging in a Murine Model of Rhabdomyosarcoma: Correlations with Quantitative Histopathologic Features
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27828
Abstract: High cellularity and abnormal interstitial structures are some of the unfavorable factors that affect the treatment outcomes and survival of rhabdomyosarcoma (RMS) patients. read more here.
Keywords: ivim imaging; rhabdomyosarcoma; imaging murine; model rhabdomyosarcoma ... See more keywords
A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1488-4_10
Abstract: Infection is the leading cause of death and prolonged hospitalization in severely burned patients that survive the acute phase of injury. Here we describe a murine model of severe burn injury followed by subsequent postburn… read more here.
Keywords: full thickness; infection; burn injury; murine model ... See more keywords
Metabolic syndrome contributes to renal injury mediated by hyperoxaluria in a murine model of nephrolithiasis
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DOI: 10.1007/s00240-017-0979-9
Abstract: Metabolic syndrome (MS) individuals have a higher risk of developing chronic kidney disease through unclear pathogenic mechanisms. MS has been also related with higher nephrolithiasis prevalence. To establish the influence of MS on renal function,… read more here.
Keywords: group; murine model; nephrolithiasis; metabolic syndrome ... See more keywords
Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis
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DOI: 10.1007/s10753-017-0605-6
Abstract: Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a… read more here.
Keywords: blood flow; sepsis; survival mesenteric; murine model ... See more keywords
Modulation of the Gut Microbiome and Obesity Biomarkers by Lactobacillus Plantarum KC28 in a Diet-Induced Obesity Murine Model
Sign Up to like & getrecommendations! Published in 2020 at "Probiotics and Antimicrobial Proteins"
DOI: 10.1007/s12602-020-09720-0
Abstract: Lactobacillus plantarum KC28 showed a beneficial (anti-obesity) effect in a diet-induced obese (DIO) C57BL/6 murine model receiving an intermediate high-fat diet (IF). This diet was selected for probiotic studies by prior comparisons of different combinations… read more here.
Keywords: obesity; kc28; plantarum kc28; murine model ... See more keywords
Investigation of thiosemicarbazide free or within chitosan nanoparticles in a murine model of vulvovaginal candidiasis
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-020-00326-w
Abstract: Vulvovaginal candidiasis is a serious health problem affecting numerous women around the world. Its treatment is based on antifungals which may not provide an effective cure because of the resistance presented by its etiological pathogens… read more here.
Keywords: candidiasis; vulvovaginal candidiasis; chitosan nanoparticles; nanoparticles murine ... See more keywords
Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2016.12.003
Abstract: BACKGROUND AND AIMS In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling,… read more here.
Keywords: airway remodelling; ursodeoxycholic acid; apoptosis; effects ursodeoxycholic ... See more keywords
Impaired amygdala-based learning and decreased anxiety in a murine model of pseudohypoparathyroidism type 1A
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.03.041
Abstract: ABSTRACT Pseudohypoparathyroidism type 1A (PHP1A) is a genetic disorder caused by maternally inherited mutations in the gene Gnas. PHP1A is characterized by multiple hormone impairment, early onset obesity and cognitive impairment. Animal models of PHP1A… read more here.
Keywords: based learning; murine; anxiety; murine model ... See more keywords
PPAR-gamma pathways attenuate pulmonary granuloma formation in a carbon nanotube induced murine model of sarcoidosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.061
Abstract: Peroxisome proliferator activated receptor gamma (PPARγ), a ligand activated nuclear transcription factor, is constitutively expressed in alveolar macrophages of healthy individuals. PPARγ deficiencies have been noted in several lung diseases including the alveolar macrophages of… read more here.
Keywords: ppar; mwcnt induced; murine model; sarcoidosis ... See more keywords