Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13796
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a disease with poor prognosis due to diagnostic and therapeutic limitations. We previously identified cystatin A (CSTA) as a PDAC biomarker and have conducted the present study to investigate the… read more here.
Keywords: csta; antitumor; murine models; dendritic cells ... See more keywords
Murine Models of Allergic Asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_10
Abstract: Allergic asthma is a heterogeneous inflammatory lung disease affecting millions of people worldwide and with a steadily increasing incidence. Mouse models have been of utmost importance in uncovering key inflammatory cell types, cytokines, and pathways… read more here.
Keywords: murine models; inflammatory; biology; asthma ... See more keywords
Quantification of Leishmania Parasites in Murine Models of Visceral Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9210-2_16
Abstract: Visceral leishmaniasis (VL) is mainly caused by Leishmania donovani (India and East Africa), and Leishmania infantum (Mediterranean Basin and South America) infections. Although murine models of visceral infection lack the clinicopathological aspects of VL in… read more here.
Keywords: models visceral; murine models; infection; quantification leishmania ... See more keywords
Timing behavior in genetic murine models of neurological and psychiatric diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental brain research"
DOI: 10.1007/s00221-020-06021-4
Abstract: How timing behavior is altered in different neurodevelopmental and neurodegenerative disorders is a contemporary research question. Genetic murine models (GMM) that offer high construct validity also serve as useful tools to investigate this question. But… read more here.
Keywords: disease models; murine models; genetic murine; timing behavior ... See more keywords
Murine models of accelerated aging and musculoskeletal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.03.002
Abstract: The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the… read more here.
Keywords: models accelerated; murine models; accelerated aging; age related ... See more keywords
Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.11.001
Abstract: Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are clonal stem cell disorders, primarily affecting patients over 65 years of age. Mapping of the MDS and MDS/MPN genome identified recurrent heterozygous mutations in the RNA… read more here.
Keywords: murine models; modeling human; human rna; sf3b1 srsf2 ... See more keywords
Diet-Induced Obesity HFpEF Murine Models
Sign Up to like & getrecommendations! Published in 2018 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2018.01.004
Abstract: We read with great interest the state-of-the-art review from Valero-Munoz et al. [(1)][1] in a recent issue of JACC: Basic to Translational Science . The authors described the more commonly used murine models of heart failure… read more here.
Keywords: murine models; murine; diet induced; obesity hfpef ... See more keywords
Murine models of uremic cardiomyopathy as a necessary tool to unravel mechanisms involved in cardiorenal syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Kidney international"
DOI: 10.1016/j.kint.2021.11.023
Abstract: Chronic kidney disease (CKD) and cardiovascular disease frequently run in parallel. Herein, Soppert et al. provide an interesting meta-analysis of the effects of CKD on cardiac remodeling and/or function in mice based on the model, strain,… read more here.
Keywords: mechanisms involved; models uremic; murine models; necessary tool ... See more keywords
Pharmacokinetic Characterization of Single-Stranded DNA in Murine Models Using High-Specific-Activity 68Ga Radiolabeling Coupled with Dynamic Positron Emission Tomography
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c07282
Abstract: This study aimed to develop an efficient concentration methodology to enhance the specific activity of 68Ga. By systematically optimizing chelation parameters, we established the relationships between the molar amounts of single-stranded DNA (A20) and varying… read more here.
Keywords: stranded dna; specific activity; activity 68ga; murine models ... See more keywords
Non-murine models to investigate tumor-immune interactions in head and neck cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0776-8
Abstract: The immune response has important roles in the biology of solid tumors, including oncogenesis, tumor growth, invasion and metastasis, and response to treatment. Improved understanding of tumor-immune system interactions has provided promising therapeutic options that… read more here.
Keywords: non murine; murine models; pre clinical; tumor immune ... See more keywords
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55554-7
Abstract: Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 (FGF14)/voltage-gated Na+ channel 1.6 (Nav1.6) complex regulates excitability of medium… read more here.
Keywords: nucleus accumbens; nav1 channel; fgf14 nav1; murine models ... See more keywords