In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02368-16
Abstract: ABSTRACT Omadacycline is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP). We used a neutropenic murine pneumonia infection model to characterize the in vivo pharmacodynamic activity of omadacycline against Streptococcus pneumoniae.… read more here.
Keywords: auc mic; omadacycline; model; vivo pharmacodynamic ... See more keywords
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.988728
Abstract: Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop novel therapies, animal models are essential to bridge the gap between… read more here.
Keywords: pneumonia; murine pneumonia; variability murine; pneumonia models ... See more keywords
Comparison of in vivo activity of garenoxacin and levofloxacin in a murine pneumonia mixed-infection model by Streptococcus pneumoniae and Parvimonas micra.
Sign Up to like & getrecommendations! Published in 2019 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2019.109
Abstract: Community-acquired pneumonia (CAP) can involve mixed-infection. However, there are few studies investigating its antimicrobial activity in mixed-infection. The aim of this study was to compare the in vivo antimicrobial activity of GRNX and levofloxacin (LVFX)… read more here.
Keywords: murine pneumonia; activity; model; mixed infection ... See more keywords