Investigations on In Vivo Pharmacokinetic/Pharmacodynamic Determinants of Fosfomycin in Murine Thigh and Kidney Infection Models.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0119
Abstract: Background: Amidst the era of widespread resistance, there has been a renewed interest in older antibiotics such as fosfomycin, owing to its activity against certain resistant Gram-negative pathogens, including multidrug-resistant variants expressing extended spectrum β-lactamases… read more here.
Keywords: infection models; thigh kidney; infection; murine thigh ... See more keywords
Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection
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DOI: 10.1093/jac/dky404
Abstract: Objectives The neutropenic murine thigh infection model and a dose-fractionation approach were used to determine the pharmacokinetic/pharmacodynamic (PK/PD) relationship of LYS228, a novel monobactam antibiotic with activity against Enterobacteriaceae including carbapenem-resistant strains. Methods Mice (n = 4… read more here.
Keywords: murine; infection; neutropenic murine; model ... See more keywords
In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model
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DOI: 10.1128/aac.00250-17
Abstract: ABSTRACT Eravacycline is a novel fluorocycline antibiotic with potent activity against a broad range of pathogens, including strains with tetracycline and other drug resistance phenotypes. The goal of the studies was to determine which pharmacokinetic/pharmacodynamic… read more here.
Keywords: murine thigh; thigh infection; infection model;
In Vivo Pharmacodynamic Profile of EVER206, a Novel Polymyxin Antimicrobial, against Gram-Negative Bacteria in the Murine Thigh Infection Model
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DOI: 10.1128/aac.01738-22
Abstract: The objective was to determine the magnitude of the EVER206 free-plasma area under the concentration time curve (fAUC)/MIC target associated with bacteriostasis and 1-log10 kill against clinically relevant Gram-negative bacteria in the murine thigh model.… read more here.
Keywords: fauc mic; bacteria murine; murine thigh; model ... See more keywords