Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
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DOI: 10.3324/haematol.2019.218818
Abstract: Tissue factor is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186-Cys209 of human tissue factor shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to tissue factor procoagulant… read more here.
Keywords: tissue factor; pathology; tissue; bleeding phenotype ... See more keywords