EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3626
Abstract: The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes… read more here.
Keywords: mus81; ezh2; resistance; brca2 ... See more keywords
Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/4065580
Abstract: This project attempts to clarify the expression of MUS81 in castration-resistant prostate cancer (CRPC) and the effect on drug sensitivity to Olaparib. We collected clinical surgical samples of patients who were suffering from benign prostatic… read more here.
Keywords: mus81; crpc cells; prostate cancer; expression mus81 ... See more keywords
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-0833
Abstract: DNA replication and repair proteins play an important role in cancer initiation and progression by affecting genomic instability. The DNA endonuclease Mus81 is a DNA structure–specific endonuclease, which has been implicated in DNA replication and… read more here.
Keywords: expression; dna endonuclease; cancer; mus81 ... See more keywords
Role of PCNA and RFC in promoting Mus81-complex activity
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biology"
DOI: 10.1186/s12915-017-0429-8
Abstract: BackgroundProper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell, leading to stalling or collapse of replication forks, and has been determined… read more here.
Keywords: pcna; mus81; dna; stimulation ... See more keywords