The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109713
Abstract: Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and to direct synapse formation to defined subcellular compartments. How this selectivity is achieved molecularly… read more here.
Keywords: protein; musashi; compartment; synaptic connectivity ... See more keywords
SA61 THE ROLE OF MUSASHI RNA BINDING PROTEINS IN ASSOCIATIVE LEARNING AND MEMORY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.133
Abstract: Background The Musashi family of RNA binding proteins, MSI-1 and MSI-2, retain a pivotal role in stem cell maintenance, nervous system development and tumourigenesis. Recently, we demonstrated that the C. elegans sole ortholog, MSI-1, can… read more here.
Keywords: musashi; msi; learning memory; role ... See more keywords
Abstract 1133: Discovery of novel small molecule inhibitors of RNA-binding protein Musashi-1
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1133
Abstract: 1) Background and Objective: Musashi-1(Msi1) is an RNA-binding protein that negatively regulates translation by binding to the 3′-UTRs of target mRNAs including Numb, APC and p21WAF-1, key regulators of Notch, Wnt signaling and cell cycle… read more here.
Keywords: musashi; small molecule; rna binding; molecule inhibitors ... See more keywords
Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqaa245
Abstract: The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice… read more here.
Keywords: musashi; pou1f1 mrna; control; anterior pituitary ... See more keywords
Increased expression of the RNA-binding protein Musashi-2 is associated with immune infiltration and predicts better outcomes in ccRCC patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.949705
Abstract: RNA-binding proteins (RBPs) mainly contribute to abnormalities in posttranscriptional gene regulation. The RBP Musashi-2, an evolutionarily conserved protein, has been characterized as an oncoprotein in various tumors. However, the prognostic value and potential roles of… read more here.
Keywords: rna binding; musashi; immune infiltration; ccrcc patients ... See more keywords
Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052851
Abstract: The stem cell marker and RNA-binding protein Musashi-1 is overexpressed in endometriosis. Musashi-1-siRNA knockdown in Ishikawa cells altered the expression of stem cell related genes, such as OCT-4. To investigate the role of both human… read more here.
Keywords: notch signaling; cell; musashi; stem cell ... See more keywords