M2 muscarinic receptor activation inhibits cell proliferation and migration of rat adipose‐mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26350
Abstract: Mesenchymal stem cells (MSCs), also known as stromal mesenchymal stem cells, are multipotent cells, which can be found in many tissues and organs as bone marrow, adipose tissue and other tissues. In particular MSCs derived… read more here.
Keywords: physiology; stem cells; muscarinic receptor; mesenchymal stem ... See more keywords
Combined treatment with a β3‐adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23061
Abstract: This study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the β3‐adrenergic receptor (AR) agonist mirabegron could inhibit detrusor overactivity induced by cold stress in spontaneously hypertensive rats (SHRs). read more here.
Keywords: receptor antagonist; receptor agonist; muscarinic receptor; receptor ... See more keywords
Injecting RNA interference lentiviruses targeting the muscarinic 3 receptor gene into the bladder wall inhibits neurogenic detrusor overactivity in rats with spinal cord injury
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23894
Abstract: To investigate the effects of injecting RNA interference (RNAi) lentiviruses targeting the muscarinic 3 (M3) receptor gene into the bladder wall on bladder activity in rats with spinal cord injury (SCI). read more here.
Keywords: injecting rna; bladder; rna interference; targeting muscarinic ... See more keywords
Muscarinic-3-receptor positive allosteric modulator ASP8302 in patients with underactive bladder. A randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and urodynamics"
DOI: 10.1002/nau.24931
Abstract: AIM The aim of this study is to evaluate safety and efficacy of ASP8302, a novel positive allosteric modulator for the muscarinic M3 receptor (M3-PAM), in patients with underactive bladder (UAB). METHODS A randomized, double-blind,… read more here.
Keywords: muscarinic receptor; allosteric modulator; placebo; bladder ... See more keywords
Airborne fine particulate matter causes murine bronchial hyperreactivity via MAPK pathway‐mediated M3 muscarinic receptor upregulation
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22241
Abstract: Regarding the human health effects, airborne fine particulate matter 2.5 (PM2.5) is an important environmental risk factor. However, the underlying molecular mechanisms are largely unknown. The present study examined the hypothesis that PM2.5 causes bronchial… read more here.
Keywords: bronchial hyperreactivity; pm2; muscarinic receptor; muscarinic receptors ... See more keywords
Impact of Muscarinic M3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients: A Case-Controlled Study
Sign Up to like & getrecommendations! Published in 2017 at "CNS Drugs"
DOI: 10.1007/s40263-017-0436-x
Abstract: BackgroundM3 muscarinic receptor antagonism has been associated with glucose intolerance and disturbance of insulin secretion.ObjectiveOur objective was to examine the risk of type 2 diabetes mellitus (T2DM) in patients using antidepressants with and without M3… read more here.
Keywords: t2dm; risk; muscarinic receptor; receptor antagonism ... See more keywords
Optical approaches for visualization of arrestin binding to muscarinic receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2017.11.001
Abstract: G protein-coupled seven-transmembrane receptors (GPCRs) mediate responses to hormones, metabolites, lipids, and neurotransmitters at the cell membrane, and so they are prominent drug targets. Although many structural, biochemical, cell biological, and biophysical studies made remarkable… read more here.
Keywords: approaches visualization; optical approaches; visualization arrestin; muscarinic receptor ... See more keywords
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2017.03.014
Abstract: BACKGROUND Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate dopaminergic signaling in the reward system, and muscarinic receptor stimulation can block direct reinforcing effects of cocaine. Here, we tested the… read more here.
Keywords: allosteric modulators; muscarinic receptor; cocaine; effects cocaine ... See more keywords
The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.014
Abstract: The acetylcholine muscarinic M1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M1… read more here.
Keywords: muscarinic receptor; medication; antagonist; receptor ... See more keywords
Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2019.05.001
Abstract: The present study aimed to characterize muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine (5-HMT), and tolterodine in bladder and other tissues of rats after their oral, intravenous, or intravesical administration. Muscarinic receptors in tissues were… read more here.
Keywords: tolterodine; muscarinic receptors; muscarinic receptor; hmt ... See more keywords
Endocytic sorting and downregulation of the M2 acetylcholine receptor is regulated by ubiquitin and the ESCRT complex
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107828
Abstract: Cholinergic dysfunction plays a critical role in a number of disease states, and the loss of functional muscarinic acetylcholine receptors plays a key role in disease pathogenesis. Therefore, preventing receptor downregulation would maintain functional receptor… read more here.
Keywords: sorting downregulation; acetylcholine; endocytic sorting; muscarinic receptor ... See more keywords