Airborne fine particulate matter causes murine bronchial hyperreactivity via MAPK pathway‐mediated M3 muscarinic receptor upregulation
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22241
Abstract: Regarding the human health effects, airborne fine particulate matter 2.5 (PM2.5) is an important environmental risk factor. However, the underlying molecular mechanisms are largely unknown. The present study examined the hypothesis that PM2.5 causes bronchial… read more here.
Keywords: bronchial hyperreactivity; pm2; muscarinic receptor; muscarinic receptors ... See more keywords
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173183
Abstract: Although agonists and antagonists of muscarinic receptors have been known for long time, there is renewed interest in compounds (such as allosteric or bitopic ligands, or biased agonists) able to differently and selectively modulate these… read more here.
Keywords: carbachol dimers; primary carbamate; muscarinic receptors; dimers primary ... See more keywords
M3 but not M4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173274
Abstract: Opioids strongly inhibit GABAergic neurons in the rostromedial tegmental nucleus (RMTg) that expresses μ-opioid receptors to induce rewarding and psychomotor effects. M3 and M4 muscarinic receptors are co-localized with μ-opioid receptors at these GABAergic neurons.… read more here.
Keywords: morphine induced; morphine; acquisition morphine; muscarinic receptors ... See more keywords
Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2019.05.001
Abstract: The present study aimed to characterize muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine (5-HMT), and tolterodine in bladder and other tissues of rats after their oral, intravenous, or intravesical administration. Muscarinic receptors in tissues were… read more here.
Keywords: tolterodine; muscarinic receptors; muscarinic receptor; hmt ... See more keywords
Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.027
Abstract: &NA; Much of our understanding about how acetylcholine modulates prefrontal cortical (PFC) networks comes from behavioral experiments that examine cortical dynamics during highly attentive states. However, much less is known about how PFC is recruited… read more here.
Keywords: auditory; muscarinic receptors; auditory processing; cortical communication ... See more keywords
Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptors
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108798
Abstract: The membrane cholesterol was found to bind and modulate the function of several G-protein coupled receptors including muscarinic acetylcholine receptors. We investigated the binding of 20 steroidal compounds including neurosteroids and steroid hormones to muscarinic… read more here.
Keywords: hormones allosteric; muscarinic receptors; steroid hormones; neurosteroids steroid ... See more keywords
Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2018.06.008
Abstract: HIGHLIGHTSOxytocin treatment exhibits anxiolytic effect.Prolonged oxytocin prevents hypetrophy of cardiomyocytes.Oxytocin enhances norepinephrine uptake.Oxytocin led to enhancement gene expression of &bgr;3‐AR and M2 MR. ABSTRACT Social stress produces behavioral alterations, and autonomic and cardiac dysfunction in… read more here.
Keywords: norepinephrine transporter; treatment; socially isolated; muscarinic receptors ... See more keywords
Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63645-w
Abstract: Regenerative capability of the peripheral nervous system after injury is enhanced by Schwann cells (SCs) producing several growth factors. The clinical use of SCs in nerve regeneration strategies is hindered by the necessity of removing… read more here.
Keywords: production; schwann cells; muscarinic receptors; derived stem ... See more keywords
Clinical and prognostic associations of autoantibodies recognizing adrenergic/muscarinic receptors in patients with heart failure.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad042
Abstract: AIMS The importance of autoantibodies (AABs) against adrenergic/muscarinic receptors in heart failure (HF) is not well-understood. We investigated the prevalence and clinical/prognostic associations of four AABs recognizing the M2-muscarinic receptor or the β1-, β2-, or… read more here.
Keywords: heart failure; muscarinic receptors; adrenergic muscarinic; clinical prognostic ... See more keywords
Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.220244
Abstract: Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation. For the present project, spherical gold nanoparticles were synthesized and functionalized with the… read more here.
Keywords: gold nanoparticles; muscarinic receptors; functionalized gold; across intestinal ... See more keywords
Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-0046
Abstract: In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been… read more here.
Keywords: tumorigenesis; directly indirectly; muscarinic receptors; indirectly suppresses ... See more keywords