LAUSR

Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction.

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2 Published in 2023 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2023.0957

Abstract: Importance The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the… read more here.

Keywords: exercise; muscle; exercise intolerance; muscle mitochondrial ... See more keywords

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults

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2 Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2021.44279

Abstract: This randomized clinical trial evaluates the improvement in the 6-minute walk distance test and in leg and hand muscle endurance after use of urolithin A in patients aged 65 to 90 years. read more here.

Keywords: effect urolithin; muscle; supplementation muscle; urolithin supplementation ... See more keywords

Association of Dermatomyositis Sine Dermatitis and With Anti-Nuclear Matrix Protein 2 Autoantibodies.

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0 Published in 2020 at "JAMA neurology"

DOI: 10.1001/jamaneurol.2020.0673

Abstract: Importance Reports on dermatomyositis (DM) sine dermatitis (DMSD) are scarce, and the concept of the disease has not been widely accepted. Objective To confirm the existence of DMSD, determine its prevalence, and characterize its serologic… read more here.

Keywords: muscle; sine dermatitis; dermatomyositis sine; pathology ... See more keywords

Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults

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1 Published in 2022 at "JAMA Neurology"

DOI: 10.1001/jamaneurol.2022.1357

Abstract: Key Points Question Is there an autoantibody biomarker of immune-mediated rippling muscle disease (iRMD)? Findings In this cohort study, autoantibodies to caveolae-associated protein 4 (cavin-4) were identified and orthogonally validated in 8 of 10 patients… read more here.

Keywords: biomarker immune; disease; immune mediated; muscle ... See more keywords

Kalirin mediates Rac1 activation downstream of calcium/calmodulin‐dependent protein kinase II to stimulate glucose uptake during muscle contraction

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1 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14428

Abstract: In this study, we investigated the role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in contraction‐stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to… read more here.

Keywords: contraction; muscle; kinase; calcium calmodulin ... See more keywords

Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo

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1 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14494

Abstract: Uncoupling protein‐3 (UCP3) is a mitochondrial transmembrane protein highly expressed in the muscle that has been implicated in regulating the efficiency of mitochondrial oxidative phosphorylation. Increasing UCP3 expression in skeletal muscle enhances proton leak across… read more here.

Keywords: overexpression ucp3; vivo; muscle; efficiency ... See more keywords

T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

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0 Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12965

Abstract: Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is… read more here.

Keywords: skeletal muscle; endoplasmic reticulum; muscle; c2c12 myotubes ... See more keywords

In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device

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0 Published in 2019 at "Advanced Biosystems"

DOI: 10.1002/adbi.201800307

Abstract: Motor neurons project axons from the hindbrain and spinal cord to muscle, where they induce myofibre contractions through neurotransmitter release at neuromuscular junctions. Studies of neuromuscular junction formation and homeostasis have been largely confined to… read more here.

Keywords: motor neurons; muscle; nerve muscle; motor ... See more keywords

Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

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0 Published in 2020 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202002924

Abstract: Exposure of a young systemic milieu reveals remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been reported, the exact underlying mechanisms of putative rejuvenating factors remain elusive, mainly due… read more here.

Keywords: system; muscle; parabiosis; muscle stem ... See more keywords

Fortifying Angiogenesis in Ischemic Muscle with FGF9-Loaded Electrospun Poly(Ester Amide) Fibers.

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1 Published in 2019 at "Advanced healthcare materials"

DOI: 10.1002/adhm.201801294

Abstract: Delivery of angiogenic growth factors lessens ischemia in preclinical models but has demonstrated little benefit in patients with peripheral vascular disease. Augmenting the wrapping of nascent microvessels by mural cells constitutes an alternative strategy to… read more here.

Keywords: muscle; fgf9; poly ester; ester amide ... See more keywords

Vascularized and Innervated Skeletal Muscle Tissue Engineering.

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0 Published in 2019 at "Advanced healthcare materials"

DOI: 10.1002/adhm.201900626

Abstract: Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully… read more here.

Keywords: skeletal muscle; muscle; tissue; muscle tissue ... See more keywords