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   Articles with "muscle" as a keyword



Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction.

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recommendations! Published in 2023 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2023.0957

Abstract: Importance The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the… read more here.

Keywords: exercise; muscle; exercise intolerance; muscle mitochondrial ... See more keywords

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2021.44279

Abstract: This randomized clinical trial evaluates the improvement in the 6-minute walk distance test and in leg and hand muscle endurance after use of urolithin A in patients aged 65 to 90 years. read more here.

Keywords: effect urolithin; muscle; supplementation muscle; urolithin supplementation ... See more keywords

Long-Term Use of Muscle Relaxant Medications for Chronic Pain

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recommendations! Published in 2024 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.34835

Abstract: Key Points Question What are the effectiveness and safety of long-term use of muscle relaxant medications for the treatment of chronic pain? Findings In this systematic review of 44 studies including 2482 participants, 9 unique… read more here.

Keywords: use muscle; muscle; pain; long term ... See more keywords
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Association of Dermatomyositis Sine Dermatitis and With Anti-Nuclear Matrix Protein 2 Autoantibodies.

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recommendations! Published in 2020 at "JAMA neurology"

DOI: 10.1001/jamaneurol.2020.0673

Abstract: Importance Reports on dermatomyositis (DM) sine dermatitis (DMSD) are scarce, and the concept of the disease has not been widely accepted. Objective To confirm the existence of DMSD, determine its prevalence, and characterize its serologic… read more here.

Keywords: muscle; sine dermatitis; dermatomyositis sine; pathology ... See more keywords

Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults

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recommendations! Published in 2022 at "JAMA Neurology"

DOI: 10.1001/jamaneurol.2022.1357

Abstract: Key Points Question Is there an autoantibody biomarker of immune-mediated rippling muscle disease (iRMD)? Findings In this cohort study, autoantibodies to caveolae-associated protein 4 (cavin-4) were identified and orthogonally validated in 8 of 10 patients… read more here.

Keywords: biomarker immune; disease; immune mediated; muscle ... See more keywords

Kalirin mediates Rac1 activation downstream of calcium/calmodulin‐dependent protein kinase II to stimulate glucose uptake during muscle contraction

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14428

Abstract: In this study, we investigated the role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in contraction‐stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to… read more here.

Keywords: contraction; muscle; kinase; calcium calmodulin ... See more keywords

Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14494

Abstract: Uncoupling protein‐3 (UCP3) is a mitochondrial transmembrane protein highly expressed in the muscle that has been implicated in regulating the efficiency of mitochondrial oxidative phosphorylation. Increasing UCP3 expression in skeletal muscle enhances proton leak across… read more here.

Keywords: overexpression ucp3; vivo; muscle; efficiency ... See more keywords
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T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12965

Abstract: Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is… read more here.

Keywords: skeletal muscle; endoplasmic reticulum; muscle; c2c12 myotubes ... See more keywords

Muscular dystrophy patients show low exercise‐induced blood flow in muscles with normal strength

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recommendations! Published in 2024 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.52194

Abstract: Neuromuscular evaluation increasingly employs muscle ultrasonography to determine muscle thickness, mean grayscale echointensity, and visual semiquantitative echotexture attenuation. However, these measures provide low sensitivity for detection of mild muscle abnormality. Exercise‐induced intramuscular blood flow is… read more here.

Keywords: blood flow; muscle; exercise induced;

Decreased Serum 5-HT: Clinical Correlates and Regulatory Role in NMJ of MG.

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recommendations! Published in 2025 at "Annals of clinical and translational neurology"

DOI: 10.1002/acn3.70222

Abstract: OBJECTIVE Although 5-Hydroxytryptamine (5-HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG)… read more here.

Keywords: role; muscle contraction; muscle; serum clinical ... See more keywords

In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device

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recommendations! Published in 2019 at "Advanced Biosystems"

DOI: 10.1002/adbi.201800307

Abstract: Motor neurons project axons from the hindbrain and spinal cord to muscle, where they induce myofibre contractions through neurotransmitter release at neuromuscular junctions. Studies of neuromuscular junction formation and homeostasis have been largely confined to… read more here.

Keywords: motor neurons; muscle; nerve muscle; motor ... See more keywords