Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells.
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DOI: 10.1002/cbin.11377
Abstract: Oxidative stress, an imbalance of redox homeostasis, contributes to the pathogenesis and progress of muscle atrophy. However, it is debated whether oxidative stress is a cause or consequence of muscle atrophy. In this study, we… read more here.
Keywords: serum starvation; muscle atrophy; oxidative stress;
Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin‐Angiotensin System
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4441
Abstract: The nutritional level of vitamin D may affect musculoskeletal health. We have reported that vitamin D is a pivotal protector against tissue injuries by suppressing local renin‐angiotensin system (RAS). This study aimed to explore the… read more here.
Keywords: muscle; level; vitamin; muscle atrophy ... See more keywords
The Role of Exercise and TFAM in Preventing Skeletal Muscle Atrophy
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DOI: 10.1002/jcp.25737
Abstract: Skeletal muscle atrophy is the consequence of protein degradation exceeding protein synthesis. This arises for a multitude of reasons including the unloading of muscle during microgravity, post‐surgery bedrest, immobilization of a limb after injury, and… read more here.
Keywords: skeletal muscle; muscle; tfam; exercise ... See more keywords
Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27348
Abstract: Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors… read more here.
Keywords: skeletal muscle; muscle; antioxidant defense; atrophy ... See more keywords
Intramuscular tetanus neurotoxin reverses muscle atrophy: a randomized controlled trial in dogs with spinal cord injury.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12836
Abstract: BACKGROUND Motor symptoms of spinal cord injury (SCI) considerably impair quality of life and are associated with a high risk of secondary diseases. So far, no pharmacological treatment is available for these symptoms. Therefore, we… read more here.
Keywords: tetanus neurotoxin; muscle; muscle atrophy; reverses muscle ... See more keywords
m6 A demethylase ALKBH5 drives denervation-induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12929
Abstract: BACKGROUND Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment of primary neuropathies, it is a clinical condition that should be investigated. FoxO3 activation is… read more here.
Keywords: muscle; denervation; induced muscle; muscle atrophy ... See more keywords
Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13100
Abstract: Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a… read more here.
Keywords: muscle atrophy; pyruvate dehydrogenase; muscle; dehydrogenase kinase ... See more keywords
MicroRNA profiling of different exercise interventions for alleviating skeletal muscle atrophy in naturally aging rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13137
Abstract: Exercise is an affordable and practical strategy to alleviate several detrimental outcomes from the aging process, including sarcopenia. The elucidation of molecular mechanisms to alleviate sarcopenia is one of the most important steps towards understanding… read more here.
Keywords: exercise; muscle; muscle atrophy; exercise interventions ... See more keywords
Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13146
Abstract: Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for… read more here.
Keywords: plasma proteome; muscle; muscle atrophy; bed rest ... See more keywords
The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13159
Abstract: Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy. We investigated the roles and efficacy of the apelin–Apj system… read more here.
Keywords: apelin; chronic kidney; muscle; muscle atrophy ... See more keywords
Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13177
Abstract: Diabetes and obesity are associated with muscle atrophy that reduces life quality and lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) and immobilization (IM)‐induced muscle atrophy in mice. However, the… read more here.
Keywords: mesenchymal stromal; muscle; muscle atrophy; induced muscle ... See more keywords