Generation and Characterization of a Skeletal Muscle Cell-Based Model Carrying One Single Gne Allele: Implications in Actin Dynamics.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02549-w
Abstract: UDP-N-Acetyl glucosamine-2 epimerase/N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid. Mutation in GNE gene causes GNE myopathy (GNEM) characterized by adult-onset muscle weakness and degeneration. However, recent studies propose… read more here.
Keywords: skeletal muscle; muscle; cell based; gne ... See more keywords
Inhibition of Protein Phosphatase Methylesterase 1 Dysregulates MAP Kinase Signaling and Attenuates Muscle Cell Differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144515
Abstract: Protein phosphatase methylesterase 1 has been identified as a novel gene in skeletal muscle that is upregulated in response to neurogenic atrophy in mice. Western blot analysis confirms that Ppme1 is expressed during both muscle… read more here.
Keywords: cell differentiation; muscle; ppme1; cell ... See more keywords
ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.08.044
Abstract: Summary Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde dehydrogenase) in this pro-IH process. The expression of ALDH1A3, but… read more here.
Keywords: matricellular proteins; vascular smooth; tnc1 esm1; proliferation ... See more keywords
GW28-e0415 Nε-carboxymethyl-Lysine Inhibits the Migration of Smooth Muscle Cell Derived Foam Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.202
Abstract: To investigate the effect of Ne-carboxymethyl-Lysine (CML) on the migration of smooth muscle cell derived foam cells. A7r5 aortic smooth muscle cells were cultured in media consisting of DMEM/F12 with 10% (v/v) fetal bovine serum… read more here.
Keywords: muscle; cell derived; carboxymethyl lysine; migration smooth ... See more keywords
Vascular Endothelial and Smooth Muscle Cell Galvanotactic Response and Differential Migratory Behavior.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112447
Abstract: Chronic disease or injury of the vasculature impairs the functionality of vascular wall cells particularly in their ability to migrate and repair vascular surfaces. Under pathologic conditions, vascular endothelial cells (ECs) lose their non-thrombogenic properties… read more here.
Keywords: vascular endothelial; migration; smooth muscle; cell ... See more keywords
How does Eucommia leaf extract prevent smooth muscle cell proliferation induced by high-fat diets at the aortic tunica media?
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension Research"
DOI: 10.1038/hr.2017.22
Abstract: How does Eucommia leaf extract prevent smooth muscle cell proliferation induced by high-fat diets at the aortic tunica media? read more here.
Keywords: leaf extract; prevent smooth; smooth muscle; extract prevent ... See more keywords
MyoD is a 3D genome structure organizer for muscle cell identity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27865-6
Abstract: The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures… read more here.
Keywords: cell identity; muscle cell; muscle; myod ... See more keywords
Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29843-3
Abstract: Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal-1) is a redox-sensitive β-galactoside-binding lectin expressed in VSMCs with intracellular and extracellular localizations. Here we… read more here.
Keywords: focal adhesion; vascular smooth; adhesion; smooth muscle ... See more keywords
Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68907-1
Abstract: Given the poor track record to date of animal models for creating cardioprotective drugs, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been proposed as a therapeutically relevant human platform to guide target validation and cardiac… read more here.
Keywords: protection; inhibitors map4k4; cell death; kinase kinase ... See more keywords
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.
Sign Up to like & getrecommendations! Published in 2020 at "European heart journal"
DOI: 10.1093/eurheartj/ehaa352
Abstract: AIMS Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the… read more here.
Keywords: vascular smooth; switch; aad; dissection ... See more keywords
Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12674
Abstract: Compounds that increase the activity of the energy sensor AMP‐activated kinase (AMPK) have the potential to regulate blood glucose levels. Although rosemary extract (RE) has been reported to activate AMPK and reduce blood glucose levels… read more here.
Keywords: rosemary extract; muscle cell; carnosic acid; glucose uptake ... See more keywords