Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation
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DOI: 10.1002/advs.202203995
Abstract: Vascular smooth muscle cells (SMCs) can adapt to changes in cellular geometric cues; however, the underlying mechanisms remain elusive. Using 2D micropatterned substrates to engineer cell geometry, it is found that in comparison with an… read more here.
Keywords: dna; muscle cells; geometry; vascular smooth ... See more keywords
Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis
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DOI: 10.1002/advs.202204038
Abstract: Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is a pore‐forming effector of pyroptosis. In this study, the role of… read more here.
Keywords: muscle cells; abdominal aortic; vascular smooth; aortic aneurysm ... See more keywords
Npom‐Protected NONOate Enables Light‐Triggered NO/cGMP Signalling in Primary Vascular Smooth Muscle Cells
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DOI: 10.1002/cbic.201700683
Abstract: Diazeniumdiolates (NONOates) are a class of nitric‐oxide‐releasing substances widely used in studies of NO/cGMP signalling. Because spatiotemporal control is highly desirable for such purposes, we have synthesised a new Npom‐caged pyrrolidine NONOate. A kinetic analysis… read more here.
Keywords: vascular smooth; cgmp signalling; muscle cells; npom protected ... See more keywords
Polarization, migration, and homotypical interactions among prostatic smooth muscle cells in a laminin 111‐rich extracellular matrix
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DOI: 10.1002/cbin.11535
Abstract: Prostate cancer is a life‐threatening condition worldwide. As the tumor progresses, smooth muscle cells (SMCs) become atrophic/dedifferentiated, within a series of stromal changes named stromal reaction. Here, we tested whether a laminin 111‐rich extracellular matrix… read more here.
Keywords: microscopy; muscle cells; laminin 111; smooth muscle ... See more keywords
Cell-To-Cell Communication in the Resistance Vasculature.
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DOI: 10.1002/cphy.c210040
Abstract: The arterial vasculature can be divided into large conduit arteries, intermediate contractile arteries, resistance arteries, arterioles, and capillaries. Resistance arteries and arterioles primarily function to control systemic blood pressure. The resistance arteries are composed of… read more here.
Keywords: cell; muscle cells; resistance; vasculature ... See more keywords
Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23091
Abstract: Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains… read more here.
Keywords: lubac; apoptosis; muscle cells; vascular smooth ... See more keywords
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29272
Abstract: In this study, we established both an animal model and a cellular model of hyperuricemia (HUC). Subsequently, we treated these models with allopurinol (ALLO) to study the effect of uric acid (UA) and ALLO on… read more here.
Keywords: osteoblasts vascular; vascular smooth; muscle cells; proliferation osteoblasts ... See more keywords
Hypoxia‐induced reprogrammed myoblasts enhance the formation of neuromuscular junctions: A pioneer study
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DOI: 10.1002/jcb.30334
Abstract: We previously reported that muscle cells could reprogram into progenitors after traumatic injuries. These injury‐induced muscle stem cells (iMuSCs) have increased migration and differentiation capacities, including neuronal differentiation. Recent studies in our laboratory suggest that… read more here.
Keywords: hypoxia induced; muscle cells; formation neuromuscular; muscle ... See more keywords
Visualization of stimulus‐specific heterogeneous activation of individual vascular smooth muscle cells in aortic tissues
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DOI: 10.1002/jcp.25903
Abstract: Intercellular communication among autonomic nerves, endothelial cells (ECs), and vascular smooth muscle cells (VSMCs) plays a central role in an uninterrupted regulation of blood flow through vascular contractile machinery. Impairment of this communication is linked… read more here.
Keywords: vascular smooth; muscle cells; smooth muscle; activation ... See more keywords
Regulation of calcification in human aortic smooth muscle cells infected with high‐glucose‐treated Porphyromonas gingivalis
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DOI: 10.1002/jcp.26268
Abstract: Porphyromonas (P.) gingivalis infection leading to the periodontitis has been associated with the development of systemic diseases, including cardiovascular diseases and diabetes. However, the effect of a high concentration of glucose (HG) on the invasion… read more here.
Keywords: infection; porphyromonas gingivalis; calcification; muscle cells ... See more keywords
Shape‐dependent adhesion and endocytosis of hydroxyapatite nanoparticles on A7R5 aortic smooth muscle cells
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DOI: 10.1002/jcp.28987
Abstract: The interaction between nanohydroxyapatite (HAP) and smooth muscle cells is an important step in vascular calcification. However, the effect of the shape of HAP on adhesion and endocytosis to aortic smooth muscle cells has been… read more here.
Keywords: muscle cells; adhesion endocytosis; hap; smooth muscle ... See more keywords