Safety, feasibility and effectiveness of first in‐human administration of muscle‐derived stem/progenitor cells modified with connexin‐43 gene for treatment of advanced chronic heart failure
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.700
Abstract: To assess the safety and efficacy of transendocardial delivery of muscle‐derived stem/progenitor cells with connexin‐43 overexpression (Cx‐43‐MDS/PC) in advanced heart failure (HF). read more here.
Keywords: heart; muscle derived; heart failure; derived stem ... See more keywords
mTOR signaling plays a critical role in the defects observed in muscle‐derived stem/progenitor cells isolated from a murine model of accelerated aging
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23409
Abstract: Mice expressing reduced levels of ERCC1‐XPF (Ercc1−/Δ mice) demonstrate premature onset of age‐related changes due to decreased repair of DNA damage. Muscle‐derived stem/progenitor cells (MDSPCs) isolated from Ercc1−/Δ mice have an impaired capacity for cell… read more here.
Keywords: muscle derived; mtor signaling; derived stem; stem progenitor ... See more keywords
Molecular and immunohistochemical analysis of the urethra of female rats after induced trauma and intravenous therapy with muscle derived stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23567
Abstract: To identify the urethral migration of muscle derived stem cells (MDSCs) after intravenous (IV) injection in rats that underwent vaginal distension (VD) and to analyze the effects of MDSC in the urethra of rats after… read more here.
Keywords: muscle; muscle derived; molecular immunohistochemical; derived stem ... See more keywords
Human Skeletal Muscle-Derived Mesenchymal Stem/Stromal Cell Isolation and Growth Kinetics Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2018_201
Abstract: The most studied sources of mesenchymal stem/stromal cells (MSCs) are bone marrow and adipose tissue. However skeletal muscle represents an interesting source of diverse subpopulations of MSCs, such as paired box 7 (Pax-7)-positive satellite cells,… read more here.
Keywords: skeletal muscle; muscle; stem stromal; muscle derived ... See more keywords
Ectopical expression of FABP4 gene can induce bovine muscle-derived stem cells adipogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.067
Abstract: Fatty acid binding protein 4 (FABP4) plays a key role in Fatty acid catabolism in mammals. Findings from our previous studies have indicated that FABP4 neither affect the differentiation of bovine preadipocytes nor does it… read more here.
Keywords: fabp4; muscle derived; derived stem; expression ... See more keywords
Myobolites: muscle‐derived metabolites with paracrine and systemic effects
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.03.007
Abstract: HighlightsMuscle secretes several metabolites with paracrine and endocrine signaling functions.Skeletal muscle secretes adenosine to increase vasodilation.Cardiomyocytes secrete cAMP which ultimately reduces cardiac hypertrophy and fibrosis.Skeletal muscle secretes BAIBA to activate beta oxidation in liver and… read more here.
Keywords: skeletal muscle; muscle; metabolites paracrine; muscle derived ... See more keywords
Biomedical applications of muscle-derived stem cells: from bench to bedside
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2020.1793953
Abstract: ABSTRACT Introduction Skeletal muscle-derived stem cells (Sk-MDSCs) are considered promising sources of adult stem cell therapy. Skeletal muscle comprises approximately 40–50% of the total body mass with marked potential for postnatal adaptive response, such as… read more here.
Keywords: muscle; muscle derived; derived stem; therapy ... See more keywords
Exercise Improves Metabolism and Alleviates Atherosclerosis via Muscle-Derived Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2023 at "Aging and Disease"
DOI: 10.14336/ad.2022.1131
Abstract: Regular exercise maintains a healthy metabolic profile, while the underlying mechanisms have not been fully elucidated. Extracellular vesicles serve as an important mediator in intercellular communication. In this study, we aimed to explore whether exercise-induced… read more here.
Keywords: metabolism; extracellular vesicles; skeletal muscle; muscle ... See more keywords
Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress
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DOI: 10.15252/embr.201948804
Abstract: Mitochondrial dysfunction promotes metabolic stress responses in a cell‐autonomous as well as organismal manner. The wasting hormone growth differentiation factor 15 (GDF15) is recognized as a biomarker of mitochondrial disorders, but its pathophysiological function remains… read more here.
Keywords: systemic metabolic; muscle; muscle derived; mitochondrial stress ... See more keywords
IGF-1-induced Muscle-Derived Stem Cells as a Potential Treatment of Stress Urinary Incontinence in Female Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Urology journal"
DOI: 10.22037/uj.v19i.7066
Abstract: PURPOSE Stress urinary incontinence (SUI) is prevalent among elderly women. This study aimed to discuss the potential of muscle-derived stem cells (MDSCs)-based therapy in treating SUI by exploring the effect of Insulin-like growth factor-1 (IGF-1)… read more here.
Keywords: mdscs; muscle; stress urinary; muscle derived ... See more keywords
Muscle-derived stem cells in peripheral nerve regeneration: reality or illusion?
Sign Up to like & getrecommendations! Published in 2017 at "Regenerative medicine"
DOI: 10.2217/rme-2016-0165
Abstract: Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential… read more here.
Keywords: medicine; muscle derived; regeneration; derived stem ... See more keywords