A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502711
Abstract: Systemic inflammation associated with obesity impairs skeletal muscle function through paracrine signaling from intermuscular adipose tissue-adipose depots situated between adjacent skeletal muscle groups-as well as from visceral adipose tissue, which consist of infiltrating macrophages surrounding… read more here.
Keywords: inflamed adipose; muscle; culture; muscle dysfunction ... See more keywords
ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12915
Abstract: The prevalence of heart failure with preserved ejection fraction (HFpEF) is still increasing, and so far, no pharmaceutical treatment has proven to be effective. A key obstacle for testing new pharmaceutical substances is the availability… read more here.
Keywords: hfpef; skeletal muscle; development; muscle dysfunction ... See more keywords
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy
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DOI: 10.1002/jcb.25841
Abstract: A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), that causes oxidative stress, inflammation, and matrix degradation, which leads to multi‐pathology in different organs. Although, it is well known that hypermethylation leads to overall gene silencing… read more here.
Keywords: skeletal muscle; hhcy; muscle; hypermethylation ... See more keywords
Glycyl‐l‐histidyl‐l‐lysine‐Cu2+ rescues cigarette smoking‐induced skeletal muscle dysfunction via a sirtuin 1‐dependent pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13213
Abstract: Skeletal muscle dysfunction is an important co‐morbidity in patients with chronic obstructive pulmonary disease (COPD) and is significantly associated with increased mortality. Oxidative stress has been demonstrated an important trigger for COPD‐related skeletal muscle dysfunction.… read more here.
Keywords: skeletal muscle; muscle; glycyl histidyl; lysine ... See more keywords
Cricopharyngeus muscle dysfunction: a poorly defined disorder from diagnosis to treatment
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DOI: 10.1007/s00405-024-08644-7
Abstract: Cricopharyngeus muscle dysfunction (CPMD) is a common clinical occurrence with very few clear diagnostic criteria and multiple pathways for treatment. Incidence of CPMD is not known, but some data suggest around 25% of people with… read more here.
Keywords: treatment; disorder; language; muscle dysfunction ... See more keywords
Nelumbinis Stamen Ameliorates Chronic Restraint Stress-Induced Muscle Dysfunction and Fatigue in Mice by Decreasing Serum Corticosterone Levels and Activating Sestrin2.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06318
Abstract: Nelumbo nucifera Gaertn. is an important aquatic vegetable, and its dried stamen (Nelumbinis stamen, NS) is a valuable nutraceutical usually used as a herbal tea. Here, we used ultrahigh-performance liquid chromatography (UPLC)-quadrupole time-of-flight mass spectrometry… read more here.
Keywords: stress; dysfunction fatigue; muscle dysfunction; mice ... See more keywords
Low skeletal muscle density combined with muscle dysfunction predicts adverse events after adult cardiovascular surgery
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Preventive Cardiology"
DOI: 10.1093/eurjpc/zwab061.358
Abstract: Type of funding sources: Other. Main funding source(s): This study was supported by the Grant for Japan Society for the Promotion of Science (JSPS) KAKENHI. Although muscle dysfunction is widely known as a poor prognostic… read more here.
Keywords: muscle; adverse events; skeletal muscle; muscle dysfunction ... See more keywords
Inventing the wheel: understanding heterogeneity of response to skeletal muscle dysfunction interventions in women with COPD
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thorax-2022-219586
Abstract: Skeletal muscle dysfunction is arguably the most important manifestation of chronic obstructive pulmonary disease (COPD) for patients. It contributes to an inability to go about activities of daily living decreases quality of life, increases office… read more here.
Keywords: heterogeneity; women copd; skeletal muscle; muscle ... See more keywords
Cardiovasomobility: An Integrative Understanding of how Disuse Impacts Cardiovascular and Skeletal Muscle Health.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00607.2021
Abstract: Cardiovasomobility is a novel concept that encompasses the integration of cardiovascular and skeletal muscle function in health and disease with critical modification by physical activity, or lack thereof. Compelling evidence indicates that physical activity improves… read more here.
Keywords: cardiovasomobility; skeletal muscle; muscle; cardiovascular skeletal ... See more keywords
Abstract Or131: Novel epigenetic therapy for Smooth Muscle Dysfunction Syndrome
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DOI: 10.1161/atv.45.suppl_1.or131
Abstract: Missense pathogenic variants in ACTA2, encoding α-smooth muscle actin (SMA), predispose to thoracic aortic aneurysms, but pathogenic variants affecting the specific amino acid arginine 179 (R179) cause a more severe childhood onset phenotype termed Smooth… read more here.
Keywords: smcs; muscle; acta2; muscle dysfunction ... See more keywords
Genomic Editing of a Pathogenic Sequence Variant in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice
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DOI: 10.1161/circulationaha.125.074218
Abstract: BACKGROUND: Vascular smooth muscle cells (SMCs), the predominant cell type in the aortic wall, play a crucial role in maintaining aortic integrity, blood pressure, and cardiovascular function. Vascular SMC contractility and function depend on ACTA2… read more here.
Keywords: muscle; muscle dysfunction; smooth muscle; sequence variant ... See more keywords