Skeletal muscle insulin resistance in prediabetes: a lipidomic perspective on diacylglycerols, ceramides, and phospholipids
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DOI: 10.1038/s41598-025-22745-1
Abstract: Lipid metabolism disorders, accompanied by the accumulation of lipids, are believed to contribute to skeletal muscle insulin resistance development. These alterations may attenuate insulin signaling and glucose uptake and utilization. However, the specific roles of… read more here.
Keywords: skeletal muscle; muscle insulin; insulin; muscle ... See more keywords
Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48 h after exercise in young and old humans.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170198
Abstract: The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exercise in… read more here.
Keywords: skeletal muscle; insulin; molecular changes; muscle ... See more keywords
Comment on “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abj1696
Abstract: Yoshino et al. (Reports, 11 June 2021, p. 1224) have reported that nicotinamide mononucleotide (NMN) increases muscle insulin sensitivity in prediabetic women. However, the 13 women who received NMN had hepatic lipid content of 6.3… read more here.
Keywords: nicotinamide mononucleotide; increases muscle; sensitivity prediabetic; prediabetic women ... See more keywords
Downregulation of ALDH6A1 is a New Marker of Muscle Insulin Resistance in Type 2 Diabetes Mellitus
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DOI: 10.2147/ijgm.s343727
Abstract: Purpose Skeletal muscle insulin resistance (IR) is an important etiology of type 2 diabetes mellitus (T2DM); however, its molecular mechanism is yet to be fully defined. This study attempted to identify the gene expression patterns… read more here.
Keywords: expression; muscle; muscle insulin; type diabetes ... See more keywords
42-OR: Miro1 Negatively Regulates Skeletal Muscle Insulin Action in Mice with Diet-Induced Obesity and Hyperglycemia
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DOI: 10.2337/db25-42-or
Abstract: Introduction and Objective: Mitochondrial Rho-GTPase (MIRO1) is a critical regulator of mitochondrial trafficking and calcium homeostasis and by extension, mediates cellular energy balance and intracellular signaling. This study aimed to mechanistically decipher the role of… read more here.
Keywords: skeletal muscle; muscle insulin; insulin; none ... See more keywords
Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00789
Abstract: Introduction: The Phosphoinositide 3-kinase (PI3K) signaling pathway plays an important role in skeletal muscle insulin-stimulated glucose uptake. While whole-body and tissue specific knockout (KO) of individual or combinations of the regulatory subunits of PI3K (p85α,… read more here.
Keywords: skeletal muscle; muscle; overexpression p55; muscle insulin ... See more keywords