Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2023.0957
Abstract: Importance The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the… read more here.
Keywords: exercise; muscle; exercise intolerance; muscle mitochondrial ... See more keywords
Acute exposure to environmentally relevant levels of DDT alters muscle mitochondrial function in vivo in rats but not in vitro in L6 myotubes: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2022.03.004
Abstract: Under insulin-stimulated conditions, skeletal muscle is the largest glucose consumer in the body. Mitochondrial dysfunction and damage to this tissue from oxidative stress are linked to the pathogenesis of type 2 diabetes. Environmental exposure to… read more here.
Keywords: muscle mitochondrial; muscle; exposure; mitochondrial function ... See more keywords
A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13943
Abstract: Myotonic dystrophy type 1 (DM1) is the second most common muscular dystrophy after Duchenne and is the most prevalent muscular dystrophy in adults. DM1 patients that participate in aerobic exercise training experience several physiological benefits… read more here.
Keywords: dystrophy type; dystrophy; muscle; muscle mitochondrial ... See more keywords
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add5163
Abstract: Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported… read more here.
Keywords: muscle mitochondrial; mitochondrial biogenesis; gut microbiota;
Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00777.2018
Abstract: Measurement of skeletal muscle mitochondrial respiration requires invasive biopsy to obtain a muscle sample. Peripheral blood mononuclear cell (PBMC) mitochondrial protein content appears to reflect training status in young men; however, no studies have investigated… read more here.
Keywords: mitochondrial respiration; muscle; mitochondrial function; muscle mitochondrial ... See more keywords
Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.139826
Abstract: Chronic kidney disease (CKD) results in a progressive skeletal myopathy involving atrophy, weakness, and fatigue. Mitochondria have been thought to contribute to skeletal myopathy, however, the molecular mechanisms underlying changes in muscle metabolism in CKD… read more here.
Keywords: chronic kidney; muscle; muscle mitochondrial; ckd ... See more keywords
Bilateral NIRS measurements of muscle mitochondrial capacity: Feasibility and repeatability
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.14826
Abstract: Non‐invasive determination of mitochondrial capacity via near infrared spectroscopy (NIRS) typically involves voluntary exercise of a single muscle group followed by as many as 26 brief ischemic cuff occlusions to determine a single recovery rate… read more here.
Keywords: measurements muscle; mitochondrial capacity; capacity; nirs measurements ... See more keywords
Impact of 4 weeks of western diet and aerobic exercise training on whole‐body phenotype and skeletal muscle mitochondrial respiration in male and female mice
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15543
Abstract: High dietary fat intake induces significant whole‐body and skeletal muscle adaptations in mice, including increased capacity for fat oxidation and mitochondrial biogenesis. The impact of a diet that is high in fat and simple sugars… read more here.
Keywords: female mice; capacity; muscle; muscle mitochondrial ... See more keywords
1347-P: Improvement in Peripheral Insulin Sensitivity (IS) with Metformin (MET) in Adolescents with Type 1 Diabetes (T1D) Is Not Mediated by Muscle Mitochondrial Change
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1347-p
Abstract: T1D youth are insulin resistant and we recently demonstrated that whole-body IS improved after 3 months of MET therapy. We also found that youth with T1D and type 2 diabetes both have skeletal muscle mitochondrial… read more here.
Keywords: none; insulin; youth; improvement ... See more keywords
Lack of Increase in Muscle Mitochondrial Protein Synthesis During the Course of Aerobic Exercise and Its Recovery in the Fasting State Irrespective of Obesity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.702742
Abstract: Acute aerobic exercise induces skeletal muscle mitochondrial gene expression, which in turn can increase muscle mitochondrial protein synthesis. In this regard, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), is a master regulator of mitochondrial… read more here.
Keywords: muscle; exercise; muscle mitochondrial; protein synthesis ... See more keywords
A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14091975
Abstract: Obesity is a highly prevalent disease that can induce metabolic syndrome and is associated with a greater risk of muscular atrophy. Mitochondria play central roles in regulating the physiological metabolism of skeletal muscle; however, whether… read more here.
Keywords: muscle; muscle mitochondrial; high fat; model ... See more keywords