EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45567-4
Abstract: A low quadriceps slow-twitch (ST), oxidative (relative to fast-twitch) fiber proportion is prevalent in chronic diseases such Chronic Obstructive Pulmonary Disease (COPD) and is associated with exercise limitation and poor outcomes. Benefits of an increased… read more here.
Keywords: muscle; slow twitch; twitch oxidative; muscle phenotype ... See more keywords
Reduced non-bicarbonate skeletal muscle buffering capacity in mice with the mini-muscle phenotype
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.172478
Abstract: ABSTRACT Muscle pH decreases during exercise, which may impair function. Endurance training typically reduces muscle buffering capacity as a result of changes in fiber-type composition, but existing comparisons of species that vary in activity level… read more here.
Keywords: mini muscle; muscle; muscle buffering; muscle phenotype ... See more keywords