Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202002924
Abstract: Exposure of a young systemic milieu reveals remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been reported, the exact underlying mechanisms of putative rejuvenating factors remain elusive, mainly due… read more here.
Keywords: system; muscle; parabiosis; muscle stem ... See more keywords
Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200249
Abstract: Cellular mechanisms whereby quiescent stem cells sense tissue injury and transition to an activated state are largely unknown. Quiescent skeletal muscle stem cells (MuSCs, also called satellite cells) have elaborate, heterogeneous projections that rapidly retract… read more here.
Keywords: cells get; niche; stem; stem cells ... See more keywords
Muscle stem cells contribute to long‐term tissue repletion following surgical sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13214
Abstract: Over the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI), for which there are no… read more here.
Keywords: sepsis; muscle; contribute long; muscle stem ... See more keywords
Delta‐Like 4 Activates Notch 3 to Regulate Self‐Renewal in Skeletal Muscle Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2757
Abstract: Notch signaling is essential to maintain skeletal muscle stem cells in quiescence. However, the precise roles of different Notch receptors are incompletely defined. Here, we demonstrate a role for Notch3 (N3) in the self‐renewal of… read more here.
Keywords: skeletal muscle; self renewal; muscle stem; stem ... See more keywords
Ex Vivo Visualization and Analysis of the Muscle Stem Cell Niche.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/7651_2018_177
Abstract: Adult skeletal muscle stem cells, termed satellite cells, are essential for regenerating muscle after tissue damage. Satellite cells are located in a specialized microenvironment between muscle fibers and their surrounding basal lamina. This local niche… read more here.
Keywords: muscle; visualization; muscle stem; niche ... See more keywords
Isolation and Culture of Individual Myofibers and Their Adjacent Muscle Stem Cells from Aged and Adult Skeletal Muscle.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/7651_2019_209
Abstract: The isolation and culture of single floating myofibers with their adjacent muscle stem cells allow the analysis and comparison of muscle stem cells from aged and young mice. This method has the advantage that muscle… read more here.
Keywords: muscle; stem cells; muscle stem; isolation culture ... See more keywords
Monitoring Autophagy in Muscle Stem Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6771-1_14
Abstract: Autophagy is critical not only for the cell's adaptive response to starvation but also for cellular homeostasis, by acting as quality-control machinery for cytoplasmic components. This basal autophagic activity is particularly needed in postmitotic cells… read more here.
Keywords: cell; muscle; muscle stem; stem ... See more keywords
Characterization of Drosophila Muscle Stem Cell-Like Adult Muscle Precursors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6771-1_5
Abstract: Uncovering how muscle stem cells behave in quiescent and activated states is central to understand the basic rules governing normal muscle development and regeneration in pathological conditions. Specification of mesodermal lineages including muscle stemlike adult… read more here.
Keywords: adult muscle; muscle; stem cell; muscle stem ... See more keywords
Cell-cell contact and signaling in the muscle stem cell niche.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2021.06.003
Abstract: Muscle stem cells (also called satellite cells or SCs) rely on their local niche for regulatory signals during homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus… read more here.
Keywords: cell cell; muscle stem; niche; cell ... See more keywords
Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.037
Abstract: Muscle stem cells (MuSCs) persist in a quiescent state and activate in response to specific stimuli. The quiescent state is both actively maintained and dynamically regulated. However, analyses of quiescence have come primarily from cells… read more here.
Keywords: stem; stem cells; muscle stem; quiescent state ... See more keywords
Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.089
Abstract: Most human cancers originate from high-turnover tissues, while low-proliferating tissues, like skeletal muscle, exhibit a lower incidence of tumor development. In Duchenne muscular dystrophy (DMD), which induces increased skeletal muscle regeneration, tumor incidence is increased.… read more here.
Keywords: muscle; muscular dystrophy; give rise; muscle stem ... See more keywords