Fusion oncogenes—genetic musical chairs
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aau8231
Abstract: Ewing sarcoma–driver fusion genes can result from complex genomic rearrangements The cytogenetic definitions of many cancers predate the genome sequencing era. Indeed, some classes of cancers (largely subtypes of sarcomas, lymphomas, and leukemias) have long… read more here.
Keywords: genetic musical; musical chairs; oncogenes genetic; translocation ... See more keywords
Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.884132
Abstract: Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to some extent from… read more here.
Keywords: cdr cdr; canonical loops; cdr; musical chairs ... See more keywords