The Mut+ strain of Komagataella phaffii (Pichia pastoris) expresses PAOX1 5 and 10 times faster than Muts and Mut− strains: evidence that formaldehyde or/and formate are true inducers of PAOX1
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10793-8
Abstract: The methylotrophic yeast Komagataella phaffii is among the most popular hosts for recombinant protein synthesis. Most recombinant proteins have been expressed in the wild-type Mut+ host strain from the methanol-inducible alcohol oxidase (AOX) promoter PAOX1.… read more here.
Keywords: methanol; mut strain; komagataella phaffii; strain ... See more keywords
Sethoxydim-resistant mutants of the thermotolerant microalga Micractinium sp. accumulate significant amounts of triacylglycerol in non-stressful conditions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-019-01859-w
Abstract: Because of their high lipid content, microalgae are regarded as a potentially competitive source for biofuels. However, one of the main biotechnological challenges in algae-based biofuels is that cell division is arrested under conditions which… read more here.
Keywords: mutants thermotolerant; sethoxydim resistant; mut; resistant mutants ... See more keywords
149. Extraction-free RT-PCR to Detect SARS-CoV-2 Variants of Concern
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DOI: 10.1093/ofid/ofab466.149
Abstract: Abstract Background SARS-CoV-2 variants of concern (VOC) have challenged real-time reverse transcriptase polymerase chain reaction (RT-PCR) methods for the diagnosis of COVID-19. Methods The CDC 2019-Novel Coronavirus real-time RT-PCR panel was modified to create a… read more here.
Keywords: sars cov; pcr; cov variants; mut ... See more keywords
Abstract CT082: Capmatinib inMETex14-mutated (mut) advanced non-small cell lung cancer (NSCLC): Results from the phase II GEOMETRYmono-1study, including efficacy in patients (pts) with brain metastases (BM)
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DOI: 10.1158/1538-7445.am2020-ct082
Abstract: Background: Capmatinib is a highly selective and potent MET inhibitor that crosses the blood-brain barrier. In the GEOMETRY mono-1 study, capmatinib showed clinically meaningful response rates in pts with advanced NSCLC harboring METex14 skipping mutations,… read more here.
Keywords: capmatinib; efficacy; mut; geometry ... See more keywords
FOLFIRINOX plus cetuximab (CET) or bevacizumab (BEV) in patients (pts) with initially unresectable colorectal liver metastases (CRLM) with BRAF mutated (mut) tumors: A subgroup analysis of the UNICANCER PRODIGE 14-ACCORD 21 (METHEP2) trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3548
Abstract: 3548Background: The treatment of metastatic colorectal cancer (mCRC) pts with BRAF-mut tumors is a major challenge for physicians. They account for < 10% of mCRC, correlate with poor prognosis, and... read more here.
Keywords: folfirinox plus; cet bevacizumab; cetuximab cet; plus cetuximab ... See more keywords
Genomic landscape of de novo stage IV breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.1022
Abstract: 1022 Background: Genomic profiling of primary and recurrent metastatic breast cancer (rMBC) has revealed potential resistance mechanisms to therapy. In contrast, de novo stage IV breast cancer (DNIV) represents an opportunity to elucidate metastatic drivers… read more here.
Keywords: mut; breast cancer; dniv; novo stage ... See more keywords
KMT2C mutation associated with tumor mutational burden in small cell lung cancer.
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DOI: 10.1200/jco.2019.37.15_suppl.e20098
Abstract: e20098 Background: Immune checkpoint inhibitors are used to treat small cell lung cancer (SCLC). Tumor mutational burden (TMB) emerges as a promising predictor of immunotherapy efficacy, but the relationship between TMB and genetic features of… read more here.
Keywords: small cell; tmb muts; kmt2c; cell lung ... See more keywords
Frequency of longitudinal changes in TP53 mutation status from gene sequencing of serial tumor biopsies from a large cohort of cancer patients.
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DOI: 10.1200/jco.2021.39.15_suppl.3124
Abstract: 3124 Background: The p53 pathway is one of the most important in cancer biology, with mutation of the TP53 gene that encodes the p53 tumor suppressor protein observed in ≈50% of all cancers. We evaluated… read more here.
Keywords: status; cancer; tumor; changes tp53 ... See more keywords
Molecular profiling and targeted agents in recurrent, metastatic salivary gland tumor (R/M SGT) patients (pts) treated at two academic centers.
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DOI: 10.1200/jco.2021.39.15_suppl.6081
Abstract: 6081 Background: Treatment selection based on actionable alterations (AAs) is an appealing strategy for pts with R/M SGT. The GEMS-001 study (NCT02069730) at Princess Margaret Cancer Centre (PM) and the Vall D´Hebron Institute of Oncology… read more here.
Keywords: treatment; overexpression; tumor; oncology ... See more keywords
Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit
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DOI: 10.3389/fmolb.2022.887336
Abstract: Recognition of diseases associated with mutations of the chaperone system genes, e.g., chaperonopathies, is on the rise. Hereditary and clinical aspects are established, but the impact of the mutation on the chaperone molecule and the… read more here.
Keywords: apical domain; muscle; subunit; cct5 ... See more keywords