Dichloromethane increases mutagenic DNA damage and transformation ability in cholangiocytes and enhances metastatic potential in cholangiocarcinoma cell lines.
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DOI: 10.1016/j.cbi.2021.109580
Abstract: Dichloromethane (DCM), a widely used chlorinated solvent, is classified by IARC (2017) as probably carcinogenic to humans. Exposure to DCM has been associated with increased incidence of cholangiocarcinoma (CCA) in humans. This study aimed to… read more here.
Keywords: dna damage; mutagenic dna; cell lines; transformation ... See more keywords