Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay
Sign Up to like & getrecommendations! Published in 2018 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22151
Abstract: In vitro genotoxicity dose–response data have been investigated for their utility in modeling and assessing potential differences in mutagenic responses between machine‐generated whole smoke solutions (WSSs) from combusted cigarette tobacco products. Our previous study observed… read more here.
Keywords: whole smoke; potency; mouse lymphoma; lymphoma assay ... See more keywords
Mutagenicity and carcinogenicity of combustion emissions are impacted more by combustor technology than by fuel composition: A brief review
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22475
Abstract: Studies during the past 50 years have characterized the carcinogenicity and mutagenicity of extractable organic material (EOM) of particulate matter (PM) in ambient air and from combustion emissions. We have summarized conclusions from these studies and… read more here.
Keywords: orders magnitude; combustion; mutagenicity; span orders ... See more keywords
Mutagenicity of the Danube River: the contribution of liquid phase and particulate suspended matter.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and molecular mutagenesis"
DOI: 10.1002/em.22478
Abstract: Bioassays have been used to complement chemical characterization of aquatic mutagenicity, but the tests are usually done only with water liquid phase. Particle-bound mutagens are usually ignored, although they can be ingested by filtering organisms.… read more here.
Keywords: mutagenicity; particulate; liquid phase; water ... See more keywords
Determination of a positive response in the Ames Salmonella mutagenicity assay
Sign Up to like & getrecommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22538
Abstract: Genetic toxicology tests are used to categorize substances as genotoxic and potentially carcinogenic. In general, test results are designated as mutagenic, not mutagenic, or inconclusive and, depending on its potential use and applicable regulations, a… read more here.
Keywords: positive response; salmonella mutagenicity; determination positive; mutagenicity ... See more keywords
Genome resequencing analysis of Salmonella typhimurium LT‐2 strains TA98 and TA100 for the establishment of a next‐generation sequencing‐based mutagenicity assay
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3463
Abstract: Next‐generation sequencing (NGS) is a potentially useful technology to achieve a more precise evaluation of chemical mutagenicity. To establish NGS‐based mutagenicity assays, which enable the direct detection of chemically induced mutations in a whole genome… read more here.
Keywords: salmonella typhimurium; generation sequencing; based mutagenicity; mutagenicity ... See more keywords
Fragment Prioritization on a Large Mutagenicity Dataset
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Informatics"
DOI: 10.1002/minf.201600133
Abstract: The identification of structural alerts is one of the simplest tools used for the identification of potentially toxic chemical compounds. Structural alerts have served as an aid to quickly identify chemicals that should be either… read more here.
Keywords: structural alerts; fragment prioritization; mutagenicity dataset; mutagenicity ... See more keywords
In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2282-0
Abstract: Abstract1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice.… read more here.
Keywords: mutagenicity dioxane; mutagenicity carcinogenicity; dioxane; mutagenicity ... See more keywords
Evaluating groundwater for its probable mutagenicity and genotoxicity using in vitro bioanalytical tools
Sign Up to like & getrecommendations! Published in 2017 at "Exposure and Health"
DOI: 10.1007/s12403-017-0263-9
Abstract: The present study entails the investigation of mutagenic and genotoxic effect of groundwater samples collected from twenty four different locations of Malwa region (India) using in vitro bioassays, viz. Ames fluctuation test (with/without exogenous metabolic… read more here.
Keywords: dna damage; groundwater; water samples; using vitro ... See more keywords
MutagenPred-GCNNs: A Graph Convolutional Neural Network-Based Classification Model for Mutagenicity Prediction with Data-Driven Molecular Fingerprints.
Sign Up to like & getrecommendations! Published in 2021 at "Interdisciplinary sciences, computational life sciences"
DOI: 10.1007/s12539-020-00407-2
Abstract: An important task in the early stage of drug discovery is the identification of mutagenic compounds. Mutagenicity prediction models that can interpret relationships between toxicological endpoints and compound structures are especially favorable. In this research,… read more here.
Keywords: graph convolutional; convolutional neural; mutagenicity prediction; model ... See more keywords
Mutagenicity and estrogenicity of raw water and drinking water in an industrialized city in the Yangtze River Delta.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.07.066
Abstract: Public concern was aroused by frequently reported water pollution incidents in Taihu Lake and the Yangtze River. The pollution also caught and sustained the attention of the scientific community. From 2010 to 2016, raw water… read more here.
Keywords: raw water; yangtze river; water; mutagenicity ... See more keywords
Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109822
Abstract: Nitroaromatic compounds (NACs) are an important type of environmental organic pollutants. However, it is lack of sufficient information relating to their potential adverse effects on human health and the environment due to the limited resources.… read more here.
Keywords: classification; quantum chemistry; chemistry; nitroaromatic compounds ... See more keywords